ArticleJournal of the American Society of Nephrology : JASN2016
Renal Atp6ap2/(Pro)renin Receptor Is Required for Normal Vacuolar H+-ATPase Function but Not for the Renin-Angiotensin System.
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Article in Journal of the American Society of Nephrology : JASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
What it found
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Who cites it
56 citing papers in PubMed, 93 citations in OpenAlex.
- Trial
- Renal tubular (pro)renin receptor deletion exacerbates kidney injury inAmerican journal of physiology. Renal physiology · 2025Article
- Nephron specific ATP6AP2 knockout increases urinary excretion of fatty acids and decreases renal cortical megalin expression.Scientific reports · 2024Article
- Pendrin: linking acid base to blood pressure.Pflugers Archiv : European journal of physiology · 2024Review
- Renal Expression and Localization of the Receptor for (Pro)renin and Its Ligands in Rodent Models of Diabetes, Metabolic Syndrome, and Age-Dependent Focal and Segmental Glomerulosclerosis.International journal of molecular sciences · 2024Article
- The role of (pro)renin receptor and its soluble form in cardiovascular diseases.Frontiers in cardiovascular medicine · 2023Review
- Endothelial cell polarity and extracellular matrix composition require functional ATP6AP2 during developmental and pathological angiogenesis.JCI insight · 2022Article
- Kidney Angiotensin in Cardiovascular Disease: Formation and Drug Targeting.Pharmacological reviews · 2022Review
- Blood Pressure Elevation of Tubular Specific (P)RR Transgenic Mice and Lethal Tubular Degeneration due to Possible Intracellular Interactions between (P)RR and Alternative Renin Products.International journal of molecular sciences · 2021Article
- Knockout of Nephron ATP6AP2 Impairs Proximal Tubule Function and Prevents High-Fat Diet-Induced Obesity in Male Mice.Endocrinology · 2021Article
- Renin Cell Baroreceptor, a Nuclear Mechanotransducer Central for Homeostasis.Circulation research · 2021Article
- The evolving complexity of the collecting duct renin-angiotensin system in hypertension.Nature reviews. Nephrology · 2021Review
- Loss of Soluble (Pro)renin Receptor Attenuates Angiotensin-II Induced Hypertension and Renal Injury.Circulation research · 2021Article
- Advances in use of mouse models to study the renin-angiotensin system.Molecular and cellular endocrinology · 2021Review
- (Pro)renin receptor in the kidney: function and significance.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Review
- The HAmerican journal of physiology. Cell physiology · 2021Review
- Kidney intercalated cells and the transcription factor FOXi1 drive cystogenesis in tuberous sclerosis complex.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Diuretic Action of Apelin-13 Mediated by Inhibiting cAMP/PKA/sPRR Pathway.Frontiers in physiology · 2021Article
- COX-2-independent activation of renal (pro)renin receptor contributes to DOCA-salt hypertension in rats.American journal of physiology. Renal physiology · 2020Article
- Cryo-EM structures of intact V-ATPase from bovine brain.Nature communications · 2020Article
Corrections and comments
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Authors and funding
15 authors at 12 institutions in 7 countries.
Francesco TrepiccioneInstitut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche_S970, Paris Centre de Recherche Cardiovasculaire, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France.
Simon D GerberImagine Institute, Paris Descartes University-Sorbonne Paris Cité, Paris, France.
Florian GrahammerRenal Division, University Medical Center Freiburg, Freiburg, Germany.
Karen I López-CayuqueoInstitut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche_S970, Paris Centre de Recherche Cardiovasculaire, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France.
Véronique BaudrieInstitut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche_S970, Paris Centre de Recherche Cardiovasculaire, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France.
Teodor G PăunescuProgram in Membrane Biology/Nephrology Division, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.
Diane E CapenProgram in Membrane Biology/Nephrology Division, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.
Nicolas PicardCentre National de la Recherche Scientifique Equipe de Recherche Labelisée 8228, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche_S1138, Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, Paris, France.
R Todd AlexanderDepartment of Pediatrics, University of Alberta, Edmonton, Canada; and.
Tobias B HuberRenal Division, University Medical Center Freiburg, Freiburg, Germany.
Regine ChambreyInstitut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche_S970, Paris Centre de Recherche Cardiovasculaire, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France.
Dennis BrownProgram in Membrane Biology/Nephrology Division, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.
Pascal HouillierProgram in Membrane Biology/Nephrology Division, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts.
Dominique EladariInstitut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche_S970, Paris Centre de Recherche Cardiovasculaire, Hôpital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France; matias.simons@institutimagine.org dominique.eladari@inserm.fr.
Matias SimonsImagine Institute, Paris Descartes University-Sorbonne Paris Cité, Paris, France; matias.simons@institutimagine.org dominique.eladari@inserm.fr.
Harvard University · USInserm · FRCenter for Systems Biology · USCentro de Estudios Científicos · CLHôpital Européen Georges-Pompidou · FRParis Cardiovascular Research Center · FRPaul Scherrer Institute · CHSorbonne Paris Cité · FRSorbonne Université · FRUniversity Medical Center Freiburg · DEUniversity of Alberta · CAUniversity of Freiburg · DE
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MTransgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FLOREZ, JOSE CARLOS · 2000 to 2019
$31.4MRegulation of proton pump trafficking in kidneyR37DK042956 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2008 to 2017
$4.0MCELLULAR REGULATION OF KIDNEY EPITHELIAL CELL POLARITYR01DK042956 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 1991 to 2006
$2.2MA Nikon A1R Confocal Microscope SystemS10RR031563 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2011 to 2011
$561kTRANSMISSION ELECTRON MICROSCOPE: MELANOMAS10RR021145 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2005 to 2005
$321kRegulation of proton pump trafficking in kidneyR56DK042956 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, DENNIS · 2018 to 2018
$100kCIHR 106464-2CIHR 96175-2NCRR NIH HHS S10 RR021145NCRR NIH HHS S10 RR031563NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK057521NIDDK NIH HHS R01 DK042956NIDDK NIH HHS R37 DK042956NIDDK NIH HHS R56 DK042956
Abstract
ATPase H
Indexed as
AnimalsFemaleKidneyMaleMiceProrenin ReceptorProton-Translocating ATPasesReceptors, Cell SurfaceRenin-Angiotensin SystemVacuolar Proton-Translocating ATPasesATP6AP2 protein, mouseProrenin ReceptorProton-Translocating ATPasesReceptors, Cell SurfaceVacuolar Proton-Translocating ATPasesacidosisbalancecell biology and structureCell & Transport Physiologywater-electrolyte
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.