Evidence map›Paper›PMID 27044585›Full record

Trial reportBMJ open2016

Effects of exercise intensity and nutrition advice on myocardial function in obese children and adolescents: a multicentre randomised controlled trial study protocol.

Katrin A Dias, Jeff S Coombes, Daniel J Green, Sjaan R Gomersall, Shelley E Keating, Arnt Erik Tjonna, Siri Marte Hollekim-Strand, Mansoureh Sadat Hosseini, Torstein Baade Ro, Margrete Haram and 5 more

Registry-linked trialOpen access · goldAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01991106 (A Multi-centre Randomized Controlled Trial Examining the Effects of High Intensity Interval Training on Cardio-metabolic Outcomes in Obese Children and Adolescents), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01991106 nacompletednot on this map

A Multi-centre Randomized Controlled Trial Examining the Effects of High Intensity Interval Training on Cardio-metabolic Outcomes in Obese Children and Adolescents

TypeinterventionalSponsorNorwegian University of Science and TechnologyRan2013 to 2017Enrolled100ConditionsObesityArmsHigh intensity interval training, Moderate intensity continuous training, Nutritional advice
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Katrin A DiasSchool of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Brisbane, Queensland, Australia.
Jeff S CoombesSchool of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Brisbane, Queensland, Australia.
Daniel J GreenSchool of Sport Science, Exercise and Health, The University of Western Australia, Perth, Western Australia, Australia Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK.
Sjaan R GomersallSchool of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Brisbane, Queensland, Australia.
Shelley E KeatingSchool of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Brisbane, Queensland, Australia.
Arnt Erik TjonnaDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Siri Marte Hollekim-StrandDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Mansoureh Sadat HosseiniDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Torstein Baade RoDepartment of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway Department of Pediatrics, St. Olav's University Hospital, Trondheim, Norway.
Margrete HaramDepartment of Radiology, Trondheim University Hospital, Trondheim, Norway.
Else Marie HuuseDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Peter S W DaviesChildren's Nutrition Research Centre, The University of Queensland, Brisbane, Queensland, Australia Queensland Children's Medical Research Institute, The University of Queensland, Brisbane, Queensland, Australia.
Peter A CainHeart Care Partners, The Wesley Hospital, Brisbane, Queensland, Australia.
Gary M LeongInstitute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia Department of Paediatric Endocrinology, Lady Cilento Children's Hospital, Brisbane, Queensland, Australia.
Charlotte B IngulDepartment of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
Norwegian University of Science and Technology · NOUniversity of Queensland · AUSt Olav's University Hospital · NOChildren's Medical Research Institute · AULiverpool John Moores University · GBWesley Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe prevalence of paediatric obesity is increasing, and with it, lifestyle-related diseases in children and adolescents. High-intensity interval training (HIIT) has recently been explored as an alternate to traditional moderate-intensity continuous training (MICT) in adults with chronic disease and has been shown to induce a rapid reversal of subclinical disease markers in obese children and adolescents. The primary aim of this study is to compare the effects of HIIT with MICT on myocardial function in obese children and adolescents. METHODS AND ANALYSIS: Multicentre randomised controlled trial of 100 obese children and adolescents in the cities of Trondheim (Norway) and Brisbane (Australia). The trial will examine the efficacy of HIIT to improve cardiometabolic outcomes in obese children and adolescents. Participants will be randomised to (1) HIIT and nutrition advice, (2) MICT and nutrition advice or (3) nutrition advice. Participants will partake in supervised exercise training and/or nutrition sessions for 3 months. Measurements for study end points will occur at baseline, 3 months (postintervention) and 12 months (follow-up). The primary end point is myocardial function (peak systolic tissue velocity). Secondary end points include vascular function (flow-mediated dilation assessment), quantity of visceral and subcutaneous adipose tissue, myocardial structure and function, body composition, cardiorespiratory fitness, autonomic function, blood biochemistry, physical activity and nutrition. Lean, healthy children and adolescents will complete measurements for all study end points at one time point for comparative cross-sectional analyses. ETHICS AND DISSEMINATION: This randomised controlled trial will generate substantial information regarding the effects of exercise intensity on paediatric obesity, specifically the cardiometabolic health of this at-risk population. It is expected that communication of results will allow for the development of more effective evidence-based exercise prescription guidelines in this population while investigating the benefits of HIIT on subclinical markers of disease. TRIAL REGISTRATION NUMBER: NCT01991106.

Indexed as

DietHigh-Intensity Interval TrainingAdolescentAustraliaBlood Flow VelocityChildClinical ProtocolsExerciseFemaleHealth PromotionHeartHumansLife StyleMaleMyocardiumNorwayHigh intensity interval trainingMyocardial functionNUTRITION & DIETETICSPaediatric obesityVascular functionVisceral adipose tissue

Identifiers

PMID27044585
PMCPMC4823457
OpenAlexW2335462835

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.