Trial reportCritical care (London, England)2016
Thiamine as an adjunctive therapy in cardiac surgery: a randomized, double-blind, placebo-controlled, phase II trial.
Trial report in Critical care (London, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02322892 (Thiamine as an Adjunctive Therapy in Cardiac Surgery), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Thiamine as an Adjunctive Therapy in Cardiac Surgery
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Interventions to prevent surgical site infection in adults undergoing cardiac surgery.The Cochrane database of systematic reviews · 2024Pooled it
- Trial
- Thiamine for Renal Protection in Septic Shock (TRPSS): A Randomized, Placebo-controlled, Clinical Trial.American journal of respiratory and critical care medicine · 2023Trial
- Effects of thiamine on vasopressor requirements in patients with septic shock: a prospective randomized controlled trial.BMC anesthesiology · 2020Trial
- Thiamine Use in Hospitalized Patients: A Clinical Review.Journal of nutrition and metabolism · 2026Review
- Clinically recommended strategies for nutritional metabolic intervention in cardiac surgery: a narrative review of oral support agents and modulators on postoperative outcomes and mechanisms.Frontiers in nutrition · 2026Review
- The Pivotal Role of Thiamine Supplementation in Counteracting Cardiometabolic Dysfunctions Associated with Thiamine Deficiency.International journal of molecular sciences · 2025Review
- The Japanese Critical Care Nutrition Guideline 2024.Journal of intensive care · 2025Review
- Cellular oxygen consumption in patients with diabetic ketoacidosis.Intensive care medicine experimental · 2024Article
- Cross-Sectional Study of Thiamine Deficiency and Its Associated Risks in Emergency Care.The western journal of emergency medicine · 2024Article
- Whole blood thiamine, intravenous thiamine supplementation and delirium occurrence in the intensive care unit: retrospective cohort analyses.International journal of clinical pharmacy · 2024Article
- Reply to MuminAmerican journal of respiratory and critical care medicine · 2024Article
- Factors associated with increased lactate levels in cardiac surgeries: scoping review.Revista brasileira de enfermagem · 2024Article
- Thiamine for the Treatment of Cardiac Arrest-Induced Neurological Injury: A Randomized, Blinded, Placebo-Controlled Experimental Study.Journal of the American Heart Association · 2023Article
- The effect of cardiopulmonary bypass on blood thiamine concentration and its association with post-operative lactate concentration.Journal of cardiothoracic surgery · 2022Observational
- Is it time to reconsider the administration of thiamine alone or in combination with vitamin C in critically ill patients? A meta-analysis of clinical trial studies.Journal of intensive care · 2022Review
- Delirium in Critical Illness Patients and the Potential Role of Thiamine Therapy in Prevention and Treatment: Findings from a Scoping Review with Implications for Evidence-Based Practice.International journal of environmental research and public health · 2021Article
- Melatonin for the treatment of sepsis: the scientific rationale.Journal of thoracic disease · 2020Review
- Efficacy of Thiamine in the Treatment of Postcardiac Arrest Patients: A Randomized Controlled Study.Critical care research and practice · 2020Article
- Vitamin C and thiamine in critical illness.BJA education · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
backgroundThiamine is a vitamin that is essential for adequate aerobic metabolism. The objective of this study was to determine if thiamine administration prior to coronary artery bypass grafting would decrease post-operative lactate levels as a measure of increased aerobic metabolism.
methodsWe performed a randomized, double-blind, placebo-controlled trial of patients undergoing coronary artery bypass grafting. Patients were randomized to receive either intravenous thiamine (200 mg) or placebo both immediately before and again after the surgery. Our primary endpoint was post-operative lactate levels. Additional endpoints included pyruvate dehydrogenase activity, global and cellular oxygen consumption, post-operative complications, and hospital and intensive care unit length of stay.
resultsSixty-four patients were included. Thiamine levels were significantly higher in the thiamine group as compared to the placebo group immediately after surgery (1200 [683, 1200] nmol/L vs. 9 [8, 13] nmol/L, p < 0.001). There was no difference between the groups in the primary endpoint of lactate levels immediately after the surgery (2.0 [1.5, 2.6] mmol/L vs. 2.0 [1.7, 2.4], p = 0.75). Relative pyruvate dehydrogenase activity was lower immediately after the surgery in the thiamine group as compared to the placebo group (15% [11, 37] vs. 28% [15, 84], p = 0.02). Patients receiving thiamine had higher post-operative global oxygen consumption 1 hour after the surgery (difference: 0.37 mL/min/kg [95% CI: 0.03, 0.71], p = 0.03) as well as cellular oxygen consumption. We found no differences in clinical outcomes.
conclusionsThere were no differences in post-operative lactate levels or clinical outcomes between patients receiving thiamine or placebo. Post-operative oxygen consumption was significantly increased among patients receiving thiamine.
trial registrationclinicaltrials.gov NCT02322892, December 14, 2014.
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