ArticleEnvironmental health : a global access science source2016
Preeclampsia and toxic metals: a case-control study in Kinshasa, DR Congo.
Article in Environmental health : a global access science source, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04387565 (Analysis of Maternal Plasma/Urine/Hair Magnesium and Vanadium Levels in Preeclampsia), which is not on this map. Cited by 22 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Analysis of Maternal Plasma/Urine/Hair Magnesium and Vanadium Levels in Preeclampsia (PrE)
Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The relationship between cadmium exposure and preeclampsia: a systematic review and meta-analysis.Frontiers in medicine · 2023Pooled it
- A global perspective of correlation between maternal blood lead levels and risks of preeclampsia: An updated systematic review and meta-analysis.Frontiers in public health · 2022Pooled it
- Environmental contaminants and preeclampsia: a systematic literature review.Journal of toxicology and environmental health. Part B, Critical reviews · 2018Pooled it
- Selected Trace Elements in Blood of Women with Preeclampsia in Kongo Central, DR Congo.Biological trace element research · 2026Article
- The relationship between trace element imbalance, oxidative stress, and endothelial dysfunction in preeclampsia diagnosis.BMC pregnancy and childbirth · 2026Article
- Does magnesium, one of the treatments for preeclampsia, interact with vanadium?Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Individual, Independent, and Joint Associations of Toxic Metals and Manganese on Hypertensive Disorders of Pregnancy: Results from the MIREC Canadian Pregnancy Cohort.Environmental health perspectives · 2023Article
- The Relationship Between Preeclampsia and Arsenic Concentration in the Peripheral Blood.Biological trace element research · 2022Review
- Exposure to Metal Mixtures in Association with Cardiovascular Risk Factors and Outcomes: A Scoping Review.Toxics · 2022Article
- Association between high-risk pregnancy and environmental contaminants in the Metropolitan Region of Baixada Santista, Brazil.Environmental science and pollution research international · 2022Article
- The Role of Inorganics in Preeclampsia Assessed by Multiscale Multimodal Characterization of Placentae.Frontiers in medicine · 2022Article
- Article
- Risk factors for preeclampsia and eclampsia at a main referral maternity hospital in Freetown, Sierra Leone: a case-control study.BMC pregnancy and childbirth · 2021Article
- Drinking water contaminants in California and hypertensive disorders in pregnancy.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Association between prenatal arsenic exposure, birth outcomes, and pregnancy complications: An observational study within the National Children's Study cohort.Environmental research · 2020Observational
- Heightened susceptibility: A review of how pregnancy and chemical exposures influence maternal health.Reproductive toxicology (Elmsford, N.Y.) · 2020Review
- Trace Minerals, Heavy Metals, and Preeclampsia: Findings from the Boston Birth Cohort.Journal of the American Heart Association · 2019Article
- Urinary trace metals, maternal circulating angiogenic biomarkers, and preeclampsia: a single-contaminant and mixture-based approach.Environmental health : a global access science source · 2019Article
- Urinary concentrations of environmental metals and associating factors in pregnant women.Environmental science and pollution research international · 2019Article
- Environmental Health Research in Africa: Important Progress and Promising Opportunities.Frontiers in genetics · 2019Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreeclampsia is frequent in Kinshasa (Democratic Republic of Congo), especially during the dry season. We tested whether preeclampsia was associated with exposure to environmental metals.
methodsUsing a case-control design, 88 women hospitalized with preeclampsia (cases) and 88 healthy pregnant women from the antenatal clinic (controls) were included in the study; 67 and 109 women were enrolled during the rainy and dry season, respectively. The concentrations of 24 elements were quantified by inductively coupled plasma mass spectrometry (ICP-MS) in 24-h urine collections. Differences in the urinary excretion of metals were investigated between cases and controls, and the interaction with season was assessed.
resultsCases and controls were well matched regarding age, parity and duration of pregnancy. In controls, the urinary concentrations of most elements were substantially higher than reference values for adults from industrially developed countries, e.g. for lead: geometric mean (GM) 8.0 μg/L [25(th)-75(th) percentile 3.1-13.8]. The daily urinary excretions of 14 metals were significantly higher in women with preeclampsia than in control women, e.g. for lead: GM 61 μg/day (25(th)-75(th) percentile 8-345) in women with preeclampsia vs 9 μg/day (25(th)-75(th) percentile 3-21) in controls (p < 0.001). A significant interaction was found between season and preeclampsia for several elements, with higher urinary excretions in preeclamptic women than controls during the dry season, but not during the rainy season.
conclusionsThis study revealed not only that women with preeclampsia excrete higher amounts of several toxic metals, especially lead, than control women, but also that this excretion exhibits seasonal variation, thus possibly explaining the high incidence and seasonal variation of preeclampsia in Kinshasa. Although the exact sources of this exposure are unknown, these findings underscore the need for preventing environmental exposures to lead and other toxic metals.
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