ArticlePsychopharmacology2016
Nicotine-induced cortical activation among nonsmokers with moderation by trait cognitive control.
Article in Psychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 8 citations in OpenAlex.
- Systematic Review of Nicotine Exposure's Effects on Neural Stem and Progenitor Cells.Brain sciences · 2021Review
- Abuse of Licit and Illicit Psychoactive Substances in the Workplace: Medical, Toxicological, and Forensic Aspects.Journal of clinical medicine · 2020Review
- The Role of Cognitive Control in the Self-Regulation and Reinforcement of Smoking Behavior.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2019Review
- Cannabinoid receptor 1 (CNR1) gene variant moderates neural index of cognitive disruption during nicotine withdrawal.Genes, brain, and behavior · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
rationaleConsiderable research suggests that nicotine enhances cognitive control-related processes (e.g., attention, memory) among nicotine-deprived smokers, both in terms of behavior and neural indices (e.g., ERP, slow-wave EEG). Nicotine may also increase cognitive control among nonsmokers, and this may vary as a function of trait cognitive control. It is important to examine the effects of nicotine on cognitive control-related processes among nonsmokers as these effects may provide a path for the initiation of smoking.
objectivesThe objectives of the study were to examine in nonsmokers (1) the effect of nicotine on resting cortical activity, an indirect measure of cognitive control, and (2) trait cognitive control as a moderator of nicotine-induced cortical activity changes.
methodEighty participants were given placebo and 7-mg nicotine patches in separate sessions for this counter-balanced, double-blind, within-subject study. Resting cortical activity was measured with EEG for a 3-min period with eyes opened.
resultsAverage alpha-1 band power density values in frontal and central regions were lower during the nicotine versus placebo condition, which provides evidence of nicotine-induced cortical activation. Furthermore, those with lower self-reported cognitive control exhibited greater nicotine-induced reductions in alpha-1 power density values.
conclusionsThese individual differences in nicotine-induced cortical activation are consistent with a model of nicotine self-medication whereby individuals with lower cognitive control may find smoking more reinforcing via amelioration of related cognitive deficits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.