ArticleBiology open2016
Feliform carnivores have a distinguished constitutive innate immune response.
Article in Biology open, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Handling Stress and Sample Storage Are Associated with Weaker Complement-Mediated Bactericidal Ability in Birds but Not Bats.Physiological and biochemical zoology : PBZPooled it
- The Promise of a Pointillist Perspective for Comparative Immunology.Physiology (Bethesda, Md.) · 2024Review
- Snap-freezing in the Field: Effect of Sample Holding Time on Performance of Bactericidal Assays.Integrative and comparative biology · 2022Article
- Numeric and morphological studies of the African lion (Panthera leo leo) pectoral limb.BMC veterinary research · 2022Article
- Comparative Genomics of the Major Histocompatibility Complex (MHC) of Felids.Frontiers in genetics · 2022Review
- GPS Telemetry Reveals a Zebra With Anthrax as Putative Cause of Death for Three Cheetahs in the Namib Desert.Frontiers in veterinary science · 2021Article
- The impacts of body mass on immune cell concentrations in birds.Proceedings. Biological sciences · 2020Article
- Article
- Effect of sex and reproductive status on the immunity of the temperate batMammalian biology = Zeitschrift fur Saugetierkunde · 2019Article
- Predictors and immunological correlates of sublethal mercury exposure in vampire bats.Royal Society open science · 2017Article
- Cheetahs have a stronger constitutive innate immunity than leopards.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Determining the immunological phenotype of endangered and threatened populations is important to identify those vulnerable to novel pathogens. Among mammals, members of the order Carnivora are particularly threatened by diseases. We therefore examined the constitutive innate immune system, the first line of protection against invading microbes, of six free-ranging carnivore species; the black-backed jackal (Canis mesomelas), the brown hyena (Hyena brunnea), the caracal (Caracal caracal), the cheetah (Acinonyx jubatus), the leopard (Panthera pardus) and the lion (Panthera leo) using a bacterial killing assay. The differences in immune responses amongst the six species were independent of their foraging behaviour, body mass or social organisation but reflected their phylogenetic relatedness. The bacterial killing capacity of black-backed jackals, a member of the suborder Caniformia, followed the pattern established for a wide variety of vertebrates. In contrast, the five representatives of the suborder Feliformia demonstrated a killing capacity at least an order of magnitude higher than any species reported previously, with a particularly high capacity in caracals and cheetahs. Our results suggest that the immunocompetence of threatened felids such as the cheetah has been underestimated and its assessment ought to consider both innate and adaptive components of the immune system.
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