Evidence map›Paper›PMID 27044305›Full record

ReviewPathogens and disease2016

Pathogenic effects of glucosyltransferase from Clostridium difficile toxins.

Yongrong Zhang, Hanping Feng

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pathogens and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Yongrong ZhangDepartment of Microbial Pathogenesis, University of Maryland Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA.
Hanping FengDepartment of Microbial Pathogenesis, University of Maryland Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA hfeng@umaryland.edu.
University of Baltimore · USUniversity of Maryland, Baltimore · US

Funding

Shigella Live Vector-Based Multivalent VaccineU19AI109776 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI LEVINE, MYRON MAX · 2014 to 2018
$25.4M
Development of Vaccines against Clostridium difficile InfectionR01AI088748 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FENG, HANPING, TZIPORI, SAUL R · 2010 to 2014
$3.1M
Epithelium, dendritic cells, and Clostridium difficile associated colitisR01DK084509 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI FENG, HANPING · 2010 to 2014
$1.7M
Toxemia and systemic disease in Clostridium difficile infectionR56AI099458 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI FENG, HANPING · 2013 to 2013
$388k
NIAID NIH HHS R01 AI088748NIAID NIH HHS R01AI088748NIAID NIH HHS R56AI99458NIAID NIH HHS U19 AI109776NIDDK NIH HHS R01 DK084509NIDDK NIH HHS R01DK084509
6 · The paper itself

Abstract

The glucosyltransferase domain ofClostridium difficiletoxins modifies guanine nucleotide-binding proteins of Rho family. It is the major virulent domain of the holotoxins. Various pathogenic effects ofC. difficiletoxins in response to Rho glucosylation have been investigated including cytoskeleton damage, cell death and inflammation. The most recent studies have revealed some significant characteristics of the holotoxins that are independent of glucosylating activity. These findings arouse discussion about the role of glucosyltransferase activity in toxin pathogenesis and open up new insights for toxin mechanism study. In this review, we summarize the pathogenic effects of glucosyltransferase domain of the toxins in the past years.

Indexed as

AnimalsBacterial ToxinsCell DeathClostridioides difficileCytokinesCytoskeletonDisease Models, AnimalEnterocolitis, PseudomembranousGlucosyltransferasesHumansInflammation MediatorsBacterial ToxinsCytokinesGlucosyltransferasesInflammation MediatorsClostridium difficileglucosyltransferasepathogenesistoxins

Identifiers

PMID27044305
PMCPMC5985493
OpenAlexW2313700199

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.