ArticleProceedings of the National Academy of Sciences of the United States of America2016
Accumulation of formamide in hydrothermal pores to form prebiotic nucleobases.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Redox chemistry of early Earth and the origin of life.Communications chemistry · 2026Review
- Membraneless protocell confined by a heat flow.Nature physics · 2025Article
- Polymer Thermophoresis by Mesoscale Simulations.Macromolecules · 2024Article
- The protometabolic nature of prebiotic chemistry.Chemical Society reviews · 2023Review
- Direct Synthesis of Formamide from COJournal of the American Chemical Society · 2023Article
- Prebiotic Synthesis of ATP: A Terrestrial Volcanism-Dependent Pathway.Life (Basel, Switzerland) · 2023Article
- The Formation of RNA Pre-Polymers in the Presence of Different Prebiotic Mineral Surfaces Studied by Molecular Dynamics Simulations.Life (Basel, Switzerland) · 2022Article
- Complementary Experimental Methods to Obtain Thermodynamic Parameters of Protein Ligand Systems.International journal of molecular sciences · 2022Article
- Soret separation and thermo-osmosis in porous media.The European physical journal. E, Soft matter · 2022Article
- Towards understanding specific ion effects in aqueous media using thermodiffusion.The European physical journal. E, Soft matter · 2022Article
- Heat flows in rock cracks naturally optimize salt compositions for ribozymes.Nature chemistry · 2021Article
- Prebiotic Organic Chemistry of Formamide and the Origin of Life in Planetary Conditions: What We Know and What Is the Future.International journal of molecular sciences · 2021Review
- Thermophoresis: The Case of Streptavidin and Biotin.Polymers · 2020Article
- Thermodiffusion and hydrolysis of 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC).The European physical journal. E, Soft matter · 2019Article
- Prebiotic Syntheses Under Shock in the Water - Formamide - Potassium Bicarbonate - Sodium Hydroxide System.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2019Article
- Correlation between thermophoretic behavior and hydrophilicity for various alcoholsThe European physical journal. E, Soft matter · 2019Article
- A Universal Geochemical Scenario for Formamide Condensation and Prebiotic Chemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Review
- Considering planetary environments in origin of life studies.Nature communications · 2018Article
- Chemomimesis and Molecular Darwinism in Action: From Abiotic Generation of Nucleobases to Nucleosides and RNA.Life (Basel, Switzerland) · 2018Review
- The Prevailing Catalytic Role of Meteorites in Formamide Prebiotic Processes.Life (Basel, Switzerland) · 2018Review
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4 authors.
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Abstract
Formamide is one of the important compounds from which prebiotic molecules can be synthesized, provided that its concentration is sufficiently high. For nucleotides and short DNA strands, it has been shown that a high degree of accumulation in hydrothermal pores occurs, so that temperature gradients might play a role in the origin of life [Baaske P, et al. (2007)Proc Natl Acad Sci USA104(22):9346-9351]. We show that the same combination of thermophoresis and convection in hydrothermal pores leads to accumulation of formamide up to concentrations where nucleobases are formed. The thermophoretic properties of aqueous formamide solutions are studied by means of Infrared Thermal Diffusion Forced Rayleigh Scattering. These data are used in numerical finite element calculations in hydrothermal pores for various initial concentrations, ambient temperatures, and pore sizes. The high degree of formamide accumulation is due to an unusual temperature and concentration dependence of the thermophoretic behavior of formamide. The accumulation fold in part of the pores increases strongly with increasing aspect ratio of the pores, and saturates to highly concentrated aqueous formamide solutions of ∼85 wt% at large aspect ratios. Time-dependent studies show that these high concentrations are reached after 45-90 d, starting with an initial formamide weight fraction of[Formula: see text]wt % that is typical for concentrations in shallow lakes on early Earth.
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