ArticleProceedings of the National Academy of Sciences of the United States of America2016
Functional network inference of the suprachiasmatic nucleus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 89 citations in OpenAlex.
- Attractive and repulsive couplings between circadian pacemaker neurons promote entrainment to light-dark cycles with after-effect.Npj biological timing and sleep · 2026Article
- Article
- Toward dissection of diverse neural components in the suprachiasmatic nucleus (SCN) pacemaker network.Neurobiology of sleep and circadian rhythms · 2026Article
- Time after time - circadian clocks through the lens of oscillator theory.FEBS letters · 2026Review
- Diurnality reconfigures circadian network dynamics in the suprachiasmatic nucleus.bioRxiv : the preprint server for biology · 2026Article
- NIPS: Network Inference with Partial State measurements using forced-delay embedding.PNAS nexus · 2026Article
- Maternal circadian disruption during pregnancy and offspring diabetic cardiovascular disease risk.Frontiers in cell and developmental biology · 2026Review
- The inferred functional connectome underlying circadian synchronization in the mouse suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Suprachiasmatic nucleus-wide estimation of oscillatory temporal dynamics.PLoS computational biology · 2025Article
- The Functional Connectome Mediating Circadian Synchrony in the Suprachiasmatic Nucleus.bioRxiv : the preprint server for biology · 2024Article
- Hierarchy or Heterarchy of Mammalian Circadian Timekeepers?Journal of biological rhythms · 2024Review
- GABAergic signalling in the suprachiasmatic nucleus is required for coherent circadian rhythmicity.The European journal of neuroscience · 2024Article
- GABAProceedings of the National Academy of Sciences of the United States of America · 2024Article
- The seasons within: a theoretical perspective on photoperiodic entrainment and encoding.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- System-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning.Cell research · 2024Article
- Extensive soma-soma plate-like contact sites (ephapses) connect suprachiasmatic nucleus neurons.The Journal of comparative neurology · 2024Article
- The Suprachiasmatic Nucleus at 50: Looking Back, Then Looking Forward.Journal of biological rhythms · 2024Review
- Article
- Astrocytic control of extracellular GABA drives circadian timekeeping in the suprachiasmatic nucleus.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Hyperammonaemia disrupts daily rhythms reversibly by elevating glutamate in the central circadian pacemaker.Liver international : official journal of the International Association for the Study of the Liver · 2023Article
Corrections and comments
- Erratum issued
- Erratum issued
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
In the mammalian suprachiasmatic nucleus (SCN), noisy cellular oscillators communicate within a neuronal network to generate precise system-wide circadian rhythms. Although the intracellular genetic oscillator and intercellular biochemical coupling mechanisms have been examined previously, the network topology driving synchronization of the SCN has not been elucidated. This network has been particularly challenging to probe, due to its oscillatory components and slow coupling timescale. In this work, we investigated the SCN network at a single-cell resolution through a chemically induced desynchronization. We then inferred functional connections in the SCN by applying the maximal information coefficient statistic to bioluminescence reporter data from individual neurons while they resynchronized their circadian cycling. Our results demonstrate that the functional network of circadian cells associated with resynchronization has small-world characteristics, with a node degree distribution that is exponential. We show that hubs of this small-world network are preferentially located in the central SCN, with sparsely connected shells surrounding these cores. Finally, we used two computational models of circadian neurons to validate our predictions of network structure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.