Evidence map›Paper›PMID 27044046›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2016

Agent-Based Modeling of Cancer Stem Cell Driven Solid Tumor Growth.

Jan Poleszczuk, Paul Macklin, Heiko Enderling

Abstract read
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jan PoleszczukDepartment of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33647, USA.
Paul MacklinCenter for Applied Molecular Medicine, University of Southern California, Los Angeles, CA, 90033, USA.
Heiko EnderlingDepartment of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, 33647, USA. heiko.enderling@moffitt.org.

Funding

(PQB6)An Integrative Computational and Bioengineered Tissue Model of MetastasisR01CA180149 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AGUS, DAVID B, ATALA, ANTHONY · 2013 to 2016
$2.3M
NCI NIH HHS R01 CA180149
6 · The paper itself

Abstract

Computational modeling of tumor growth has become an invaluable tool to simulate complex cell-cell interactions and emerging population-level dynamics. Agent-based models are commonly used to describe the behavior and interaction of individual cells in different environments. Behavioral rules can be informed and calibrated by in vitro assays, and emerging population-level dynamics may be validated with both in vitro and in vivo experiments. Here, we describe the design and implementation of a lattice-based agent-based model of cancer stem cell driven tumor growth.

Indexed as

Computer SimulationCell CommunicationCell ProliferationHumansNeoplasmsNeoplastic Stem CellsAgent-based modelCalibrationCancer stem cellDigital cell lineDomainHigh performanceSearch orderTumor growth

Identifiers

PMID27044046
PMCPMC6587968

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.