Evidence map›Paper›PMID 27044037›Full record

SynthesisJournal of neurovirology2016

Risk of intracerebral hemorrhage in HIV/AIDS: a systematic review and meta-analysis.

Réza Behrouz, Christopher Hans Topel, Ali Seifi, Lee A Birnbaum, Robin L Brey, Vivek Misra, Mario Di Napoli

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Journal of neurovirology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Impact of Depressive Symptom Severity on Stroke Risk in a US Cohort of People with HIV.Journal of acquired immune deficiency syndromes (1999) · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Prevention of stroke in people living with HIV.Progress in cardiovascular diseases
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Réza BehrouzDivision of Cerebrovascular Diseases, Department of Neurology, School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA. behrouz@uthscsa.edu.
Christopher Hans TopelDivision of Cerebrovascular Diseases, Department of Neurology, School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
Ali SeifiDepartment of Neurological Surgery, School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
Lee A BirnbaumDivision of Cerebrovascular Diseases, Department of Neurology, School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
Robin L BreyDivision of Cerebrovascular Diseases, Department of Neurology, School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
Vivek MisraDivision of Cerebrovascular Diseases, Department of Neurology, School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
Mario Di NapoliNeurological Service, San Camillo de' Lellis General Hospital, Rieti and the Neurological Section, Neuro-epidemiology Unit, SMDN, Centre for Cardiovascular Medicine and Cerebrovascular Disease Prevention, Sulmona, L'Aquila, Italy.
The University of Texas Health Science Center at San Antonio · USNeurological Surgery · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence for the association and the increased risk of stroke with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) is growing. Recent studies have reported on HIV infection as a potent risk factor for intracerebral hemorrhage (ICH). We used the pooled results from case-control studies to conduct a systematic review and a meta-analysis in order to evaluate the risk of ICH with HIV/AIDS. Our systematic review and meta-analysis was based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses algorithm of all available case-control studies that reported on the risk of ICH in patients with HIV/AIDS. Five eligible studies were identified, totaling 5,310,426 person-years studied over various periods that ranged from 1985 to 2010. There were a total of 724 cases of ICH, 138 with HIV/AIDS. HIV-infected ICH patients were in average younger. Pooled crude incidence rate ratio (IRR) for ICH in HIV/AIDS patients was 3.40 (95 % confidence intervals [CI] 1.44-8.04; p = 0.005, random-effects model). Clinical AIDS was associated with a higher IRR of ICH (11.99, 95 % CI 2.84-50.53; p = 0.0007) than HIV+ status without AIDS (1.73, 95 % CI 1.39-2.16; p < 0.0001). Patients with CD4

Indexed as

AdultAnti-HIV AgentsCase-Control StudiesCD4 Lymphocyte CountCerebral HemorrhageDisease ProgressionFemaleHIV InfectionsHumansMaleMiddle AgedRisk FactorsStrokeAnti-HIV AgentsAcquired immunodeficiency syndromeHuman immunodeficiency virusIntracerebral hemorrhageMeta-analysisStroke

Identifiers

PMID27044037
OpenAlexW2336030937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.