Evidence map›Paper›PMID 27043948›Full record

ReviewEating and weight disorders : EWD2016

Obesity or obesities? Controversies on the association between body mass index and premature mortality.

Ottavio Bosello, Maria Pia Donataccio, Massimo Cuzzolaro

Abstract readReview
PubMed Publisher
In one paragraph

Review in Eating and weight disorders : EWD, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  11. Body shape index: an index for early target organ damage in hypertension.American journal of translational research · 2025
    Article
  12. Editorial: Obesity across the life course.Frontiers in public health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ottavio BoselloDepartment of Medicine, Gerontology Unit, University of Verona, 37126, Verona, Italy.
Maria Pia DonataccioDepartment of Medicine, Division of Cardiology, University of Verona, 37126, Verona, Italy.
Massimo CuzzolaroFormerly Experimental Medicine Department, Medical Pathophysiology Section, Sapienza University of Rome, 57021, Campiglia Marittima, LI, Italy. massimo.cuzzolaro@gmail.com.ORCID http://orcid.org/0000-0002-4961-9512

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is still defined on the basis of body mass index (BMI) and BMI in itself is generally accepted as a strong predictor of overall early mortality. However, an inverse association between BMI and mortality has been reported in patients with many disease states and in several clinical settings: hemodialysis, cardiovascular diseases, hypertension, stroke, diabetes, chronic obstructive pulmonary disease, surgery, etc. This unexpected phenomenon is usually called obesity-survival paradox (OP). The contiguous concepts of metabolically healthy obesity (MHO, a phenotype having BMI ≥ 30 but not having any metabolic syndrome component and having a homeostasis model assessment of insulin resistance, HOMA, <2.5) and metabolically obese normal weight (MONW, normal-weight individuals displaying obesity-related phenotypic characteristics) have received a great deal of attention in recent years. The interactions that link MHO, MONW and OP with body composition, fat distribution, aging and cardiorespiratory fitness are other crucial areas of research. The article is an introductory narrative overview of the origin and current use of the concepts of MHO, MONW and OP. These phenomena are very controversial and appear as a consequence of the frail current diagnostic definition of obesity based only on BMI. A new commonly established characterization and classification of obesities based on a number of variables is needed urgently.

Indexed as

Body Mass IndexInsulin ResistanceHumansMetabolic SyndromeMortality, PrematureObesityBody mass indexMetabolically healthy obesityMetabolically obese normal weightObesityObesity paradox

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.