Evidence map›Paper›PMID 27043843›Full record

ArticleEndocrine2017

Vitamin D receptor gene polymorphisms/haplotypes and serum 25(OH)D

Salvatore Giovinazzo, Teresa M Vicchio, Rosaria Certo, Angela Alibrandi, Orazio Palmieri, Alfredo Campennì, Salvatore Cannavò, Francesco Trimarchi, Rosaria Maddalena Ruggeri

Abstract read
PubMed Publisher
In one paragraph

Article in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 4 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Effects of vitamin D supplements on frequency of CD4European journal of clinical nutrition · 2019
    Trial
  6. Article
  7. Article
  8. Observational
  9. Autoimmune Thyroiditis and Vitamin D.International journal of molecular sciences · 2024
    Review
  10. Review
  11. Review
  12. Vitamin D and the Thyroid: A Critical Review of the Current Evidence.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Implication ofBalkan journal of medical genetics : BJMG · 2020
    Article
  19. Observational
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Salvatore GiovinazzoUnit of Endocrinology, Department of Clinical and Experimental Medicine, University of Messina, AOU Policlinico "G. Martino" (Pad H, Floor 4), Via Consolare Valeria, 1, 98125, Messina, Italy.
Teresa M VicchioUnit of Endocrinology, Department of Clinical and Experimental Medicine, University of Messina, AOU Policlinico "G. Martino" (Pad H, Floor 4), Via Consolare Valeria, 1, 98125, Messina, Italy.
Rosaria CertoUnit of Endocrinology, Department of Clinical and Experimental Medicine, University of Messina, AOU Policlinico "G. Martino" (Pad H, Floor 4), Via Consolare Valeria, 1, 98125, Messina, Italy.
Angela AlibrandiDepartment of Economics, University of Messina, Messina, Italy.
Orazio PalmieriCasa Sollievo Sofferenza Hospital, IRCCS, San Giovanni Rotondo, Italy.
Alfredo CampennìDepartment of Biomedical Sciences and Morpho-Functional Imaging, University of Messina, Messina, Italy.
Salvatore CannavòUnit of Endocrinology, Department of Clinical and Experimental Medicine, University of Messina, AOU Policlinico "G. Martino" (Pad H, Floor 4), Via Consolare Valeria, 1, 98125, Messina, Italy.
Francesco TrimarchiUnit of Endocrinology, Department of Clinical and Experimental Medicine, University of Messina, AOU Policlinico "G. Martino" (Pad H, Floor 4), Via Consolare Valeria, 1, 98125, Messina, Italy.
Rosaria Maddalena RuggeriUnit of Endocrinology, Department of Clinical and Experimental Medicine, University of Messina, AOU Policlinico "G. Martino" (Pad H, Floor 4), Via Consolare Valeria, 1, 98125, Messina, Italy. rmruggeri@unime.it.
University of Messina · ITCasa Sollievo della Sofferenza · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D deficiency and/or reduced function, as per certain polymorphisms of the vitamin D receptor (VDR) gene, have been related to several autoimmune disorders. The present study was aimed to investigate the association of Hashimoto's thyroiditis with vitamin D status and functional polymorphisms (SNPs) of the VDR gene. In this case-control study, 200 euthyroid subjects were enrolled: 100 newly diagnosed HT patients (87 F, 13 M; mean age ± SD 42 ± 15 year) and 100 healthy individuals, matched for age, sex, BMI, and month of blood sampling. Serum 25(OH)D

Indexed as

HaplotypesPolymorphism, Single NucleotideAdultAgedCalcifediolCase-Control StudiesFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHashimoto DiseaseHumansMaleMiddle AgedReceptors, CalcitriolYoung AdultCalcifediolReceptors, CalcitriolAutoimmunityHashimoto’s thyroiditisSingle nucleotide polymorphismsVitamin DVitamin D receptor gene (VDR)

Identifiers

PMID27043843
OpenAlexW2340430143

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.