ArticleBioconjugate chemistry2016
Synthesis of Diverse (11)C-Labeled PET Radiotracers via Direct Incorporation of [(11)C]CO2.
Article in Bioconjugate chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Current Landscape of Glycogen Synthase Kinase-3β PET Tracers: Progress, Limitations, and Perspectives-A Narrative Review.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Synthesis and preliminary evaluation of novel PET probes for GSK-3 imaging.Scientific reports · 2024Article
- Synthesis and Evaluation of a Novel PET Radioligand for Imaging Glutaminyl Cyclase Activity as a Biomarker for Detecting Alzheimer's Disease.ACS sensors · 2024Article
- Druggability of Targets for Diagnostic Radiopharmaceuticals.ACS pharmacology & translational science · 2023Review
- Reactive Palladium-Ligand Complexes forPharmaceuticals (Basel, Switzerland) · 2023Review
- Radiochemistry for positron emission tomography.Nature communications · 2023Review
- Palladium-Mediated Synthesis of [Carbonyl-The Journal of organic chemistry · 2023Article
- Acyl Amidines by Pd-Catalyzed Aminocarbonylation: One-Pot Cyclizations andThe Journal of organic chemistry · 2023Article
- Radiofluorination of oxazole-carboxamides for preclinical PET neuroimaging of GSK-3.Journal of fluorine chemistry · 2021Article
- Synthesis of RadiopharmaceuticalsFrontiers in nuclear medicine · 2021Article
- Radiosynthesis of [Frontiers in nuclear medicine · 2021Article
- Chemistry for Positron Emission Tomography: Recent Advances inAngewandte Chemie (International ed. in English) · 2019Review
- Direct Incorporation of [Journal of chemistry · 2018Article
- Synthesis and pre-clinical evaluation of a potential radiotracer for PET imaging of the dopamine DMedChemComm · 2018Article
- Late-Stage Isotopic Carbon Labeling of Pharmaceutically Relevant Cyclic Ureas Directly from COAngewandte Chemie (International ed. in English) · 2018Article
- In-loop flow [Journal of labelled compounds & radiopharmaceuticals · 2018Article
- "In-loop" [Journal of labelled compounds & radiopharmaceuticals · 2018Article
- Recent progress in [Journal of labelled compounds & radiopharmaceuticals · 2018Article
- High-Yielding Automated Convergent Synthesis of No-Carrier-Added [Synlett : accounts and rapid communications in synthetic organic chemistry · 2017Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Three new positron emission tomography (PET) radiotracers of interest to our functional neuroimaging and translational oncology programs have been prepared through new developments in [(11)C]CO2 fixation chemistry. [(11)C]QZ (glutaminyl cyclase) was prepared via a tandem trapping of [(11)C]CO2/intramolecular cyclization; [(11)C]tideglusib (glycogen synthase kinase-3) was synthesized through a tandem trapping of [(11)C]CO2 followed by an intermolecular cycloaddition between a [(11)C]isocyanate and an isothiocyanate to form the 1,2,4-thiadiazolidine-3,5-dione core; [(11)C]ibrutinib (Bruton's tyrosine kinase) was synthesized through a HATU peptide coupling of an amino precursor with [(11)C]acrylic acid (generated from [(11)C]CO2 fixation with vinylmagnesium bromide). All radiochemical syntheses are fully automated on commercial radiochemical synthesis modules and provide radiotracers in 1-5% radiochemical yield (noncorrected, based upon [(11)C]CO2). All three radiotracers have advanced to rodent imaging studies and preliminary PET imaging results are also reported.
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