SynthesisMedicine2016
Significantly Higher Prevalence Rate of Asthma and Bipolar Disorder Co-Morbidity: A Meta-Analysis and Review Under PRISMA Guidelines.
Synthesis in Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Specificity of environmental risk factors for schizophrenia, bipolar disorders, and depressive disorders - umbrella review.Psychological medicine · 2025Pooled it
- Respiratory disease in people with bipolar disorder: a systematic review and meta-analysis.Molecular psychiatry · 2025Pooled it
- Strength of association between comorbidities and asthma: a meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Associations between lifestyle, genetic liability for severe mental illness and risk of incident somatic illnesses.Translational psychiatry · 2026Article
- Risk Factors Associated with Longitudinal Trajectories of Mania Symptoms in Youth.medRxiv : the preprint server for health sciences · 2026Article
- Somatic morbidity in bipolar disorders.International journal of bipolar disorders · 2026Article
- Factors that influence participation in physical activity for people with bipolar disorder: a synthesis of qualitative evidence.The Cochrane database of systematic reviews · 2024Review
- Healthcare Utilization, Physical and Psychiatric Comorbidities Before Self-Injurious Behavior in Patients with Asthma: A Nested Case-Control Study.Journal of asthma and allergy · 2024Article
- Association between the epigenetic lifespan predictor GrimAge and history of suicide attempt in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Asthma Prevalence and its Risk Factors Among a Multi-Ethnic Adult Population.The Yale journal of biology and medicine · 2021Article
- Development of a biomarker database toward performing disease classification and finding disease interrelations.Database : the journal of biological databases and curation · 2021Article
- Memory Function, Neurological, and Immunological Biomarkers in Allergic Asthmatic Mice Intratracheally Exposed to Bisphenol A.International journal of environmental research and public health · 2019Article
- The relationship between asthma and depression in a community-based sample.The Journal of asthma : official journal of the Association for the Care of Asthma · 2018Article
- Gender Differences and Comorbidities in U.S. Adults with Bipolar Disorder.Brain sciences · 2018Article
- Epidemiology and risk factors for bipolar disorder.Therapeutic advances in psychopharmacology · 2018Review
- ITGB4 deficiency in bronchial epithelial cells directs airway inflammation and bipolar disorder-related behavior.Journal of neuroinflammation · 2018Article
- Medical Comorbidities in Bipolar Disorder.Current psychiatry reports · 2018Review
- Examining the Moderating Effect of Sex on the Association Between Asthma and Age of Onset in Bipolar Disorder and Schizophrenia.Journal of the Academy of Consultation-Liaison PsychiatryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Asthma and bipolar disorder (BD) are 2 distinct diseases that share similar pathophysiology. This study aimed to determine their relationship thorough a meta-analysis of articles on their comorbidity rate. The aim of the study is to examine the overall prevalence rate of BD in asthmatic patients and of asthma in BD patients compared to healthy controls. Electronic research of PubMed and ClinicalTrials.gov was performed. Articles discussing the prevalence rate of BD in patients with/without asthma and the prevalence rate of asthma in those with/without BD, as well as clinical trials in humans and case-controlled trials or cohort studies, were all included. Case reports or series and nonclinical trials were excluded. Through a random-effects model, a meta-analysis of the results of 4 studies comparing the prevalence rate of BD in patients with/without asthma, and in 6 studies comparing the prevalence rate of asthma in subjects with/without BD were performed. There were significantly higher prevalence rates of BD in asthmatic patients than in healthy controls (P < 0.001) and of asthma in BD patients than in healthy controls (P < 0.001). Only the patient's mean age significantly modulated the odds ratio of the prevalence rate of asthma in BD patients (slope = 0.015, P < 0.001). Only 10 studies were included and most were cross-sectional studies. The possible confounding effect of medication on BD or asthma onset was not investigated. Any possible etiology of the comorbidity was also not determined. This meta-analysis highlights the importance of the significantly high comorbid rate of BD and asthma, and the positive association with age. Special attention must be given to the comorbidity of asthma and BD, especially in older patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.