Evidence map›Paper›PMID 27043663›Full record

ArticleOncogenesis2016

MicroRNA-206 is differentially expressed in Brca1-deficient mice and regulates epithelial and stromal cell compartments of the mouse mammary gland.

A Wronski, G K Sandhu, M J G Milevskiy, B L Brewster, J A Bridge, A M Shewan, S L Edwards, J D French, M A Brown

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncogenesis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. MicroRNAs: A Link between Mammary Gland Development and Breast Cancer.International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

A WronskiSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia.
G K SandhuSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia.
M J G MilevskiySchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia.
B L BrewsterSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia.
J A BridgeSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia.
A M ShewanSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia.
S L EdwardsSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia.
J D FrenchSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia.
M A BrownSchool of Chemistry and Molecular Biosciences, University of Queensland, St Lucia, Queensland, Australia.
University of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Depletion of Brca1 leads to defects in mouse mammary gland development and mammary tumors in humans and mice. To explore the role of microRNAs (miRNAs) in this process, we examined the mammary glands of MMTV-Cre Brca1(Co/Co) mice for differential miRNA expression using a candidate approach. Several miRNAs were differentially expressed in mammary tissue at day 1 of lactation and in mammary epithelial cell lines in which Brca1 messenger RNA (mRNA) levels have been reduced. Functional studies revealed that several of these miRNAs regulate mammary epithelial cell function in vitro, including miR-206. Creation and analysis of MMTV-miR-206 transgenic mice showed no effect on lactational mammary development and no tumors, but indicates a role in mammary tissue remodeling in mature mice, potentially involving Igf-1 and Sfrp1. These results indicate the potential of miRNAs to mediate the consequences of Brca1 loss and suggest a novel function for miR-206.

Identifiers

PMID27043663
PMCPMC4848838
OpenAlexW2340405103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.