Evidence map›Paper›PMID 27043636›Full record

ReviewPathogens (Basel, Switzerland)2016

The Role of Autophagy-Related Proteins in Candida albicans Infections.

Jenny M Tam, Michael K Mansour, Mridu Acharya, Anna Sokolovska, Allison K Timmons, Adam Lacy-Hulbert, Jatin M Vyas

Open access · goldAbstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Loss of Fgr41 inInfection and immunity · 2026
    Article
  3. The roles ofFrontiers in medicine · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. It takes a village: Phagocytes play a central role in fungal immunity.Seminars in cell & developmental biology · 2019
    Review
  14. Article
  15. Review
  16. Phagocytosis ofOxidative medicine and cellular longevity · 2018
    Article
  17. The Absence of NOD1 Enhances Killing ofFrontiers in immunology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jenny M TamDepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. jmtam@mgh.harvard.edu.
Michael K MansourDepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. mkmansour@mgh.harvard.edu.
Mridu AcharyaImmunology Program, Benaroya Research Institute, Seattle, WA 98101, USA. macharya@benaroyaresearch.org.
Anna SokolovskaDepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. anyasokol@gmail.com.
Allison K TimmonsDepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. atimmons1@mgh.harvard.edu.
Adam Lacy-HulbertImmunology Program, Benaroya Research Institute, Seattle, WA 98101, USA. adamlh@benaroyaresearch.org.
Jatin M VyasDepartment of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. jvyas@mgh.harvard.edu.
Harvard University · USBenaroya Research Institute

Funding

Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Ramnik J Xavier · 1991 to 2026
$35.3M
INFECTIOUS DISEASE AND BASIC MICROBIOLOGICAL MECHANISMST32AI007061 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Marcia B Goldberg · 1985 to 2026
$12.1M
Functional Role of the Tetraspanin CD82/Kai1 in Innate and Adaptive ImmunityR01AI092084 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2011 to 2015
$2.2M
The role of TLR9 on Aspergillus fumigatus phagosomesR01AI097519 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2013 to 2016
$1.6M
Dendritic Cell Control of Intestinal T Cell ResponsesR01DK093695 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI LACY-HULBERT, ADAM · 2012 to 2015
$1.4M
Subcellular Mechanisms for Fungal Phagosome Maturation in MacrophagesK08AI110655 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MANSOUR, MICHAEL K · 2014 to 2017
$759k
Systems Analysis of Innate Immune Responses to Fungal-Derived CarbohydratesR21AI109303 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2015 to 2016
$479k
NIAID NIH HHS K08 AI110655NIAID NIH HHS R01 AI092084NIAID NIH HHS R01 AI097519NIAID NIH HHS R21 AI109303
6 · The paper itself

Abstract

Autophagy plays an important role in maintaining cell homeostasis by providing nutrients during periods of starvation and removing damaged organelles from the cytoplasm. A marker in the autophagic process is the reversible conjugation of LC3, a membrane scaffolding protein, to double membrane autophagosomes. Recently, a role for LC3 in the elimination of pathogenic bacteria and fungi, including Candida albicans (C. albicans), was demonstrated, but these organisms reside in single membrane phagosomes. This process is distinct from autophagy and is termed LC3-associated phagocytosis (LAP). This review will detail the hallmarks of LAP that distinguish it from classical autophagy and review the role of autophagy proteins in host response to C. albicans and other pathogenic fungi.

Indexed as

Aspergillus fumigatusautophagyCandida albicansDectin-1innate immunityLC3LC3-associated phagocytosis (LAP)

Identifiers

PMID27043636
PMCPMC4931385
OpenAlexW2332584019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.