ArticleToxins2016
Mechanisms that Determine the Differential Stability of Stx⁺ and Stx(-) Lysogens.
Article in Toxins, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Factors Governing the Cross-Species Virulence of Shiga Toxin-ProducingPathogens (Basel, Switzerland) · 2026Article
- Key roles of two-component systems in intestinal signal sensing and virulence regulation in enterohemorrhagic Escherichia coli.FEMS microbiology reviews · 2024Review
- A prophage encoded ribosomal RNA methyltransferase regulates the virulence of Shiga-toxin-producing Escherichia coli (STEC).Nucleic acids research · 2024Article
- Antimicrobial growth promoters approved in food-producing animals in South Africa induce shiga toxin-converting bacteriophages from Escherichia coli O157:H7.Gut pathogens · 2023Article
- Differences in the Shiga Toxin (Stx) 2a Phage Regulatory Switch Region Influence Stx2 Localization and Virulence of Stx-ProducingMicroorganisms · 2023Article
- Article
- Prophage Activation in the Intestine: Insights Into Functions and Possible Applications.Frontiers in microbiology · 2021Review
- Fighting Fire with Fire: Phage Potential for the Treatment ofAntibiotics (Basel, Switzerland) · 2018Article
- Influence of RNase E deficiency on the production of stx2-bearing phages and Shiga toxin in an RNase E-inducible strain of enterohaemorrhagic Escherichia coli (EHEC) O157:H7.Journal of medical microbiology · 2018Article
- Molecular Mechanisms Governing "Hair-Trigger" Induction of Shiga Toxin-Encoding Prophages.Viruses · 2018Article
- Article
- Phage Therapy: Beyond Antibacterial Action.Frontiers in medicine · 2018Article
- Shigatoxin encoding Bacteriophage ϕ24Scientific reports · 2017Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phages 933W, BAA2326, 434, and λ are evolutionarily-related temperate lambdoid phages that infect Escherichia coli. Although these are highly-similar phages, BAA2326 and 933W naturally encode Shiga toxin 2 (Stx⁺), but phage 434 and λ do not (Stx(-)). Previous reports suggest that the 933W Stx⁺ prophage forms less stable lysogens in E. coli than does the Stx(-) prophages λ, P22, and 434. The higher spontaneous induction frequency of the Stx⁺ prophage may be correlated with both virulence and dispersion of the Stx2-encoding phage. Here, we examined the hypothesis that lysogen instability is a common feature of Stx⁺ prophages. We found in both the absence and presence of prophage inducers (DNA damaging agents, salts), the Stx⁺ prophages induce at higher frequencies than do Stx(-) prophages. The observed instability of Stx⁺ prophages does not appear to be the result of any differences in phage development properties between Stx⁺ and Stx(-) phages. Our results indicate that differential stability of Stx⁺ and Stx(-) prophages results from both RecA-dependent and RecA-independent effects on the intracellular concentration of the respective cI repressors.
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