ArticleMarine drugs2016
Influences of Fucoxanthin on Alveolar Bone Resorption in Induced Periodontitis in Rat Molars.
Article in Marine drugs, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Tropical Seaweeds as a Sustainable Resource Towards Circular Bioeconomy: Insights and Way Forward.Molecular biotechnology · 2026Review
- Evaluation of Systemic Lutein Supplementation on Periodontal Repair in Experimental Periodontitis in Wistar Rats.Dentistry journal · 2026Article
- Serum carotenoids modify the association between porphyromonas gingivalis IgG and mortality: a prospective cohort study with 25.8 years of follow-up.BMC nutrition · 2026Article
- Unleashing the power of microalgae: a pioneering path to sustainability and achieving the sustainable development goals.Environmental science and pollution research international · 2025Review
- Investigation of the preventive effect of methylsulfonylmethane on alveolar bone loss and oxidative stress in a rat model of periodontitis.BMC oral health · 2025Article
- Influence of platelet-rich plasma on RANKL and IL-1 immunohistochemical expression in periodontitis-related bone cell proliferation and differentiation.The Saudi dental journal · 2024Article
- Fucoxanthin alleviates the cytotoxic effects of cadmium and lead on a human osteoblast cell line.Toxicology research · 2024Article
- Osteoclastogenesis Inhibitor and Antioxidant Properties of Konjac Glucomannan in a Periodontitis Mice Model: An In Vivo Study.International journal of dentistry · 2023Article
- Association between Dietary Habit and Clinical Parameters in Patients with Chronic Periodontitis Undergoing Supportive Periodontal Therapy.Nutrients · 2022Article
- Links between Insulin Resistance and Periodontal Bacteria: Insights on Molecular Players and Therapeutic Potential of Polyphenols.Biomolecules · 2022Review
- Fucoxanthin: A Promising Phytochemical on Diverse Pharmacological Targets.Frontiers in pharmacology · 2022Review
- Fucoxanthin Suppresses Osteoclastogenesis via Modulation of MAP Kinase and Nrf2 Signaling.Marine drugs · 2021Article
- Marine Bioactive Compounds as Nutraceutical and Functional Food Ingredients for Potential Oral Health.Frontiers in nutrition · 2021Review
- Cyanobacteria and Microalgae as Sources of Functional Foods to Improve Human General and Oral Health.Molecules (Basel, Switzerland) · 2020Review
- Carotenoids and Periodontal Infection.Nutrients · 2020Review
- Therapeutic effects of caffeic acid phenethyl ester on alveolar bone loss in rats with endotoxin-induced periodontitis.Journal of dental sciences · 2019Article
- The Osteogenic Potential of Brown Seaweed Extracts.Marine drugs · 2019Article
- Bioactive Compounds from Marine Organisms: Potential for Bone Growth and Healing.Marine drugs · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the effects of systemic fucoxanthin treatment on alveolar bone resorption in rats with periodontitis. Thirty rats were divided into control, experimental periodontitis (EP), and experimental periodontitis-fucoxanthin (EP-FUCO) groups. Periodontitis was induced by ligature for four weeks. After removal of the ligature, the rats in the EP-FUCO group were treated with a single dose of fucoxanthin (200 mg/kg bw) per day for 28 consecutive days. At the end of the study, all of the rats were euthanized and intracardiac blood and mandible tissue samples were obtained for biochemical, immunohistochemical, and histometric analyses. Fucoxanthin treatment resulted in a slight decrease in tumor necrosis factor-α, interleukin-1β, and interleukin-6 levels and a significant decrease in oxidative stress index. It was observed that fucoxanthin caused a significant reduction in receptor activator of nuclear factor kappa-β ligand (RANKL) levels and a statistically non-significant elevation in osteoprotegerin and bone-alkaline phosphatase levels. There were no significant differences in alveolar bone loss levels between the EP and EP-FUCO groups. This experimental study revealed that fucoxanthin provides a limited reduction in alveolar bone resorption in rats with periodontitis. One of the mechanisms underlying the mentioned limited effect might be related to the ability of fucoxanthin to inhibit oxidative stress-related RANKL-mediated osteoclastogenesis.
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