ReviewInternational journal of molecular sciences2016
Linking Pesticide Exposure with Pediatric Leukemia: Potential Underlying Mechanisms.
Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 87 citations in OpenAlex.
- Water pollution and childhood leukaemia risk: a systematic review.Ecancermedicalscience · 2026Review
- Acute lymphoblastic leukemia: an update on treatment and Brazilian perspective.Frontiers in oncology · 2026Review
- Pre- and Postnatal Exposures to Residential Pesticides and Survival of Childhood Acute Lymphoblastic Leukemia.Cancers · 2025Article
- Article
- Evidence concerning parental exposure to pesticides and the occurrence of leukemia in offspring: a systematic review.Frontiers in pediatrics · 2025Review
- Pesticide Exposures during Pregnancy and Health Outcomes in Latin America and the Caribbean: A Scoping Review of Human Observational Studies.Journal of health & pollution · 2024Review
- Incidence of Pediatric Cancers in French Guiana: How Does It Compare to Global Estimates?Cancers · 2024Article
- Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro.International journal of molecular sciences · 2023Article
- The emerging scenario of immunotherapy for T-cell Acute Lymphoblastic Leukemia: advances, challenges and future perspectives.Experimental hematology & oncology · 2023Review
- Childhood acute lymphoblastic leukemia survival and spatial analysis of socio-environmental risks in Mexico.Frontiers in oncology · 2023Article
- Monitoring residues of pesticides in food in Brazil: A multiscale analysis of the main contaminants, dietary cancer risk estimative and mechanisms associated.Frontiers in public health · 2023Article
- Chlorpyrifos Occurrence and Toxicological Risk Assessment: A Review.International journal of environmental research and public health · 2022Review
- Pesticide residues on children's hands, home indoor surfaces, and drinking water among conventional and organic farmers in Thailand.Environmental monitoring and assessment · 2022Article
- Epigenetic Inheritance: Intergenerational Effects of Pesticides and Other Endocrine Disruptors on Cancer Development.International journal of molecular sciences · 2022Review
- Assessment of Pediatric Cancer and Its Relationship to Environmental Contaminants: An Ecological Study in Idaho.GeoHealth · 2022Article
- Pesticide exposure and related health problems among farmworkers' children: a case-control study in southeast Iran.Environmental science and pollution research international · 2021Article
- Reducing dermal exposure to agrochemical carcinogens using a fluorescent dye-based intervention among subsistence farmers in rural Honduras.International journal of hygiene and environmental health · 2021Article
- Childhood Acute Leukemias in Developing Nations: Successes and Challenges.Current oncology reports · 2021Review
- A sensing approach for automated and real-time pesticide detection in the scope of smart-farming.Computers and electronics in agriculture · 2020Article
- Risk of genotoxic damage in schoolchildren exposed to organochloride pesticides.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Leukemia is the most common cancer in children, representing 30% of all childhood cancers. The disease arises from recurrent genetic insults that block differentiation of hematopoietic stem and/or progenitor cells (HSPCs) and drives uncontrolled proliferation and survival of the differentiation-blocked clone. Pediatric leukemia is phenotypically and genetically heterogeneous with an obscure etiology. The interaction between genetic factors and environmental agents represents a potential etiological driver. Although information is limited, the principal toxic mechanisms of potential leukemogenic agents (e.g., etoposide, benzene metabolites, bioflavonoids and some pesticides) include topoisomerase II inhibition and/or excessive generation of free radicals, which may induce DNA single- and double-strand breaks (DNA-DSBs) in early HSPCs. Chromosomal rearrangements (duplications, deletions and translocations) may occur if these lesions are not properly repaired. The initiating hit usually occurs in utero and commonly leads to the expression of oncogenic fusion proteins. Subsequent cooperating hits define the disease latency and occur after birth and may be of a genetic, epigenetic or immune nature (i.e., delayed infection-mediated immune deregulation). Here, we review the available experimental and epidemiological evidence linking pesticide exposure to infant and childhood leukemia and provide a mechanistic basis to support the association, focusing on early initiating molecular events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.