ReviewInternational journal of molecular sciences2016
Mechanism of Sleep Disturbance in Children with Atopic Dermatitis and the Role of the Circadian Rhythm and Melatonin.
Review in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Prevalence of sleep disorders in atopic dermatitis: a systematic review and meta-analysis.Archives of dermatological research · 2025Pooled it
- Sleep Efficiency and Neurocognitive Decline in Atopic Dermatitis: A Systematic Review.Acta dermato-venereologica · 2024Pooled it
- Influence of light at night on allergic diseases: a systematic review and meta-analysis.BMC medicine · 2024Pooled it
- Efficacy, Safety, and Long-Term Disease Control of Ruxolitinib Cream Among Adolescents with Atopic Dermatitis: Pooled Results from Two Randomized Phase 3 Studies.American journal of clinical dermatology · 2024Trial
- Emerald Touchless Sensor Quantifies Nighttime Scratching and Sleep Quality in Children With Atopic Dermatitis: PEDISTAD EMERALD Study.Dermatology and therapy · 2026Article
- Sleep Disturbance and Atopic Dermatitis: A Bidirectional Relationship With Clinical and Therapeutic Implications.Cureus · 2026Review
- Digital Exposure and Skin Health in Children and Adolescents: A State-of-the-Art Review.Cureus · 2026Review
- Evaluation of sleep quality, social-emotional development, and parental stress levels of children with atopic dermatitis.European journal of pediatrics · 2026Article
- Is There a Relationship Between Serum BDNF Levels, Disease Severity, and Psychiatric Symptoms in Adolescents with Atopic Dermatitis?Children (Basel, Switzerland) · 2025Article
- Insomnia Associated With Increased Risk of Atopic Dermatitis: A Two-Sample Mendelian Randomization Study.Brain and behavior · 2025Article
- Evidences for gestures associated with pruritus in very young infants: a pilot study.Scientific reports · 2025Article
- Paediatric Atopic Dermatitis: The Unexpected Impact on Life with a Specific Look at the Molecular Level.International journal of molecular sciences · 2024Review
- Cycloolivil Isolated fromInternational journal of molecular sciences · 2024Article
- Sleep and allergic diseases among young Chinese adults from the Singapore/Malaysia Cross-Sectional Genetic Epidemiology Study (SMCGES) cohort.Journal of physiological anthropology · 2024Article
- Atopic Dermatitis: Disease Background and Risk Factors.Advances in experimental medicine and biology · 2024Article
- Melatonergic Signaling Sustains Food Allergy Through FcεRI Recycling.Research (Washington, D.C.) · 2024Article
- Investigation of possible relationship between atopic dermatitis and salivary biomarkers, stress, and sleep disorders.World journal of clinical cases · 2023Review
- Impact of Crisaborole on Sleep Outcomes in Pediatric Patients with Mild-to-Moderate Atopic Dermatitis.Dermatology and therapy · 2023Article
- Study protocol: assessing SleeP IN infants with early-onset atopic Dermatitis by Longitudinal Evaluation (The SPINDLE study).BMC pediatrics · 2022Observational
- Exploring genetic association of insomnia with allergic disease and asthma: a bidirectional Mendelian randomization study.Respiratory research · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sleep disturbance is common in children with atopic dermatitis (AD). It is a major factor leading to impaired quality of life in these patients and could have negative effects on neurocognitive function and behavior. However, the pathophysiology of sleep disturbance in children with AD is poorly understood, and there is no consensus on how to manage sleep problems in these patients. Pruritus and scratching could lead to sleep disruption but is unlikely the sole etiology. The circadian rhythm of cytokines, the immune system, and skin physiology such as transcutaneous water loss and skin blood flow might also play a role. Recent studies have suggested that melatonin could also be involved due to its multiple effects on sleep, immunomodulation, and anti-oxidant ability. Environmental factors should also be considered. In this review, we summarize the current understanding of the pathophysiology of sleep disturbance in children with AD, and discuss possible therapeutic implications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.