ArticleInternational journal of molecular sciences2016
TOR Pathway-Mediated Juvenile Hormone Synthesis Regulates Nutrient-Dependent Female Reproduction in Nilaparvata lugens (Stål).
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed, 80 citations in OpenAlex.
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- Role of nuclear protein Akirin in the modulation of female reproduction inFrontiers in physiology · 2024Article
- Nutrients limit production of insects for food and feed: an emphasis on nutritionally essential amino acids.Animal frontiers : the review magazine of animal agriculture · 2023Article
- MiR-2b-2-5p regulates lipid metabolism and reproduction by targetingRNA biology · 2023Article
- The Phosphoserine Phosphatase Alters the Free Amino Acid Compositions and Fecundity inInternational journal of molecular sciences · 2022Article
- RNA interference knockdown of insulin receptor inhibits ovarian development in Chilo suppressalis.Molecular biology reports · 2022Article
- Interaction of Liberibacter Solanacearum with Host Psyllid Vitellogenin and Its Association with Autophagy.Microbiology spectrum · 2022Article
- A chromosome-level genome assembly provides insights into the environmental adaptability and outbreaks of Chlorops oryzae.Communications biology · 2022Article
- Overexpression of an Osa-miR162a Derivative in Rice Confers Cross-Kingdom RNA Interference-Mediated Brown Planthopper Resistance without Perturbing Host Development.International journal of molecular sciences · 2021Article
- Neuropeptide Bursicon Influences Reproductive Physiology inFrontiers in physiology · 2021Article
- FoxO directly regulates the expression of TOR/S6K and vitellogenin to modulate the fecundity of the brown planthopper.Science China. Life sciences · 2021Article
- Genome-Wide Identification and Characterization of Amino Acid Polyamine Organocation Transporter Family Genes Reveal Their Role in Fecundity Regulation in a Brown Planthopper Species (Frontiers in physiology · 2021Article
- Involvement ofFrontiers in physiology · 2021Article
- The Desaturase GeneInternational journal of molecular sciences · 2020Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The "target of rapamycin" (TOR) nutritional signaling pathway and juvenile hormone (JH) regulation of vitellogenesis has been known for a long time. However, the interplay between these two pathways regulating vitellogenin (Vg) expression remains obscure. Here, we first demonstrated the key role of amino acids (AAs) in activation of Vg synthesis and egg development in Nilaparvata lugens using chemically defined artificial diets. AAs induced the expression of TOR and S6K (S6 kinase), whereas RNAi-mediated silencing of these two TOR pathway genes and rapamycin application strongly inhibited the AAs-induced Vg synthesis. Furthermore, knockdown of Rheb (Ras homologue enriched in brain), TOR, S6K and application of rapamycin resulted in a dramatic reduction in the mRNA levels of jmtN (juvenile hormone acid methyltransferase, JHAMT). Application of JH III on the RNAi (Rheb and TOR) and rapamycin-treated females partially rescued the Vg expression. Conversely, knockdown of either jmtN or met (methoprene-tolerant, JH receptor) and application of JH III had no effects on mRNA levels of Rheb, TOR and S6K and phosphorylation of S6K. In summary, our results demonstrate that the TOR pathway induces JH biosynthesis that in turn regulates AAs-mediated Vg synthesis in N. lugens.
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