ArticleMolecules (Basel, Switzerland)2016
Silymarin Prevents Restraint Stress-Induced Acute Liver Injury by Ameliorating Oxidative Stress and Reducing Inflammatory Response.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 64 citations in OpenAlex.
- Silymarin attenuates oxidative, inflammatory and apoptotic damage induced by a fungicide mixture in rat liver, kidney and brain.Toxicology reports · 2026Article
- Synergic Treatment of Plant-Based Antioxidants with Iron Chelators for Iron Overload in Transfusion-Dependent-Thalassemia Patients: A Systematic Review.International journal of hematology-oncology and stem cell research · 2025Review
- Milk Thistle (Current medicinal chemistry · 2025Review
- The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANES.Frontiers in psychiatry · 2025Article
- Silybin restores glucose uptake after tumour necrosis factor-alpha and lipopolysaccharide stimulation in 3T3-L1 adipocytes.Adipocyte · 2024Article
- Social defeat stress induces liver injury by modulating endoplasmic reticulum stress in C57BL/6J mice.Scientific reports · 2024Article
- The effects of restraint stress on ceramide metabolism disorders in the rat liver: the role of CerS6 in hepatocyte injury.Lipids in health and disease · 2024Article
- Silymarin and Inflammation: Food for Thoughts.Antioxidants (Basel, Switzerland) · 2024Review
- Article
- Effects of silybin supplementation on growth performance, serum indexes and liver transcriptome of Peking ducks.Frontiers in veterinary science · 2023Article
- Mechanistic Insights into the Pharmacological Significance of Silymarin.Molecules (Basel, Switzerland) · 2022Review
- Shibi Tea (Nutrients · 2022Article
- Effects of synthetic silymarin-PLGA nanoparticles on M2 polarization and inflammatory cytokines in LPS-treated murine peritoneal macrophages.Iranian journal of basic medical sciences · 2021Article
- Comparative Analysis of the Antioxidative and Hepatoprotective Activities of Dimethyl Diphenyl Bicarboxylate in Four Animal Models of Hepatic Injury.Antioxidants (Basel, Switzerland) · 2021Article
- Protective Effects of Silymarin Against D-Gal/LPS-Induced Organ Damage and Inflammation in Mice.Drug design, development and therapy · 2021Article
- Hepatoprotective effect of limonene against chronic immobilization induced liver damage in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Silybum marianum (milk thistle) improves vancomycin induced nephrotoxicity by downregulating apoptosis.Molecular biology reports · 2020Article
- An Herbal Formula CGFrontiers in pharmacology · 2020Article
- Dexmedetomidine improves acute stress-induced liver injury in rats by regulating MKP-1, inhibiting NF-κB pathway and cell apoptosis.Journal of cellular physiology · 2019Article
- Silymarin's Inhibition and Treatment Effects for Alzheimer's Disease.Molecules (Basel, Switzerland) · 2019Review
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Silymarin is a flavonoid extracted from the milk thistle Silybum marianum. It has been reported to prevent liver injuries induced by various chemicals or toxins. Our recent study suggested that silymarin induces hepatic synthesis of glutathione by increasing cysteine availability, which may consequently contribute to increased antioxidant capacity of the liver. In the present study, we investigated the effects of silymarin on acute liver injury induced by restraint stress. Silymarin (100 mg/kg) was orally administered to BALB/c mice every 12 h (3 times in total). After the last dose, mice were subjected to restraint stress for 6 h, and serum levels of aspartate and alanine aminotransferases, and hepatic levels of lipid peroxidation were determined. Hepatic levels of sulfur-containing metabolites such as methionine, S-adenosylmethionine, cysteine, and glutathione were also measured. The level of pro-inflammatory mediators in both liver and serum was determined. To study the mechanism of the effects of silymarin, we assessed Jun N-terminal kinase (JNK) activation and apoptotic signaling. Restraint stress induced severe oxidative stress and increased mRNA levels of pro-inflammatory mediators; both effects of restraint stress were significantly inhibited by silymarin. Moreover, administration of silymarin significantly prevented acute liver injury induced by restraint stress by blocking JNK activation and subsequently apoptotic signaling. In conclusion, these results suggest that the inhibition of restraint stress-induced liver injury by silymarin is due at least in part to its anti-oxidant activity and its ability to suppress the inflammatory response.
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