Evidence map›Paper›PMID 27043347›Full record

ReviewKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2016

Non-surgical treatments for the management of early osteoarthritis.

Giuseppe Filardo, Elizaveta Kon, Umile Giuseppe Longo, Henning Madry, Paolo Marchettini, Antonio Marmotti, Dieter Van Assche, Giacomo Zanon, Giuseppe M Peretti

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04998188 (Hydrolyzed Collagen Formulation Versus Placebo in the Treatment of Degenerative Knee Cartilage Injuries), which is not on this map. Cited by 85 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 15 pooled it
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04998188 narecruitingnot on this mapstarted 2022, after this paper: background citation

Hydrolyzed Collagen Formulation Versus Placebo in the Treatment of Degenerative Knee Cartilage Injuries

TypeinterventionalSponsorIstituto Ortopedico RizzoliRan2022 to 2027Enrolled204ConditionsKnee OsteoarthritisArmsCollagen, Placebo (saline solution)
3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 15 syntheses or guidelines pooled it, 146 citations in OpenAlex.

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  6. Platelet-rich plasma injections induce disease-modifying effects in the treatment of osteoarthritis in animal models.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2021
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  12. Bone bruise in anterior cruciate ligament rupture entails a more severe joint damage affecting joint degenerative progression.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2019
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  13. No evidence for combining cartilage treatment and knee osteotomy in osteoarthritic joints: a systematic literature review.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018
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  20. Step-by-step insight into gait analysis: A narrative review unlocking knee biomechanics.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026
    Review

25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 5 countries.

Giuseppe FilardoBiomechanics Lab - II Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy.
Elizaveta KonBiomechanics Lab - II Clinic, Rizzoli Orthopaedic Institute, Bologna, Italy. e.kon@biomec.ior.it.ORCID http://orcid.org/0000-0003-0649-2336
Umile Giuseppe LongoUniversity Campus Bio-Medico of Rome, Rome, Italy.
Henning MadryCenter of Experimental Orthopaedics, Department of Orthopaedic Surgery, Saarland University Medical Center, Homburg/Saar, Germany.
Paolo MarchettiniPain Medicine, Department of Neurology, Ospedale San Raffaele, Milan, Italy.
Antonio MarmottiDepartment of Orthopaedics and Traumatology, University of Torino, Turin, Italy.
Dieter Van AsscheDepartment of Rehabilitation Sciences, Research Group of Musculoskeletal Rehabilitation, KU Leuven, Louvain, Belgium.
Giacomo ZanonIRCCS, Fondazione Policlinico San Matteo, Pavia, Italy.
Giuseppe M PerettiIRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
Istituto Ortopedico Rizzoli · ITPoliclinico San Matteo Fondazione · ITSaarland University · DEUniversità Campus Bio-Medico · ITUniversitair Ziekenhuis Leuven · BEUniversity of Applied Sciences and Arts of Southern Switzerland · CHUniversity of Milan · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-surgical treatments are usually the first choice for the management of knee degeneration, especially in the early osteoarthritis (OA) phase when no clear lesions or combined abnormalities need to be addressed surgically. Early OA may be addressed by a wide range of non-surgical approaches, from non-pharmacological modalities to dietary supplements and pharmacological therapies, as well as physical therapies and novel biological minimally invasive procedures involving injections of various substances to obtain a clinical improvement and possibly a disease-modifying effect. Numerous pharmaceutical agents are able to provide clinical benefit, but no one has shown all the characteristic of an ideal treatment, and side effects have been reported at both systemic and local level. Patients and physicians should have realistic outcome goals in pharmacological treatment, which should be considered together with other conservative measures. Among these, exercise is an effective conservative approach, while physical therapies lack literature support. Even though a combination of these therapeutic options might be the most suitable strategy, there is a paucity of studies focusing on combining treatments, which is the most common clinical scenario. Further studies are needed to increase the limited evidence on non-surgical treatments and their combination, to optimize indications, application modalities, and results with particular focus on early OA. In fact, most of the available evidence regards established OA. Increased knowledge about degeneration mechanisms will help to better target the available treatments and develop new biological options, where preliminary results are promising, especially concerning early disease phases. Specific treatments aimed at improving joint homoeostasis, or even counteracting tissue damage by inducing regenerative processes, might be successful in early OA, where tissue loss and anatomical changes are still at very initial stages.

Indexed as

Exercise TherapyPhysical Therapy ModalitiesViscosupplementationAdrenal Cortex HormonesAnalgesicsAnthraquinonesAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalChondroitin SulfatesEarly Medical InterventionGlucosamineHumansHyaluronic AcidInjections, Intra-ArticularOsteoarthritis, KneeViscosupplementsAdrenal Cortex HormonesAnalgesicsAnthraquinonesAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalChondroitin SulfatesdiacereinGlucosamineHyaluronic AcidViscosupplementsCartilage degenerationConservative treatmentEarly osteoarthritisKneeNon-surgical treatment

Identifiers

PMID27043347
OpenAlexW2341682349

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.