Evidence map›Paper›PMID 27043343›Full record

ReviewKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2016

Sport and early osteoarthritis: the role of sport in aetiology, progression and treatment of knee osteoarthritis.

F Vannini, T Spalding, L Andriolo, M Berruto, M Denti, J Espregueira-Mendes, J Menetrey, G M Peretti, R Seil, G Filardo

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05450458 (Safety and Effectiveness of Hyaluronic Acid and Sorbitol With Overuse Knee Pain in Sportsmen), which is not on this map. Cited by 38 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 2 pooled it
8.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05450458 phase2 / phase3completednot on this mapstarted 2023, after this paper: background citation

Safety and Effectiveness of Hyaluronic Acid and Sorbitol With Overuse Knee Pain in Sportsmen

TypeinterventionalSponsorHospital Regional TlalnepantlaRan2023 to 2025Enrolled64ConditionsOveruse Injury, Body Mass Index in AthletesArmsKNEE JOINT INFILTRATION WITH HYALURONIC ACID WITH SORBITOL SYNOLIS VA
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Exercise-myokine relationships in osteoarthritis.Journal of translational medicine · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 8 institutions in 6 countries.

F VanniniIRCCS Istituti Ortopedici Rizzoli, Bologna, 1 Clinic, Bologna University, Bologna, Italy. francesca.vannini@ior.it.
T SpaldingUniversity Hospital Coventry and Warwickshire NHS Trust, Coventry, UK.
L AndrioloII Orthopaedic and Traumatologic Clinic - Biomechanics and Technology Innovation Laboratory, Rizzoli Orthopaedic Institute, Bologna, Italy.ORCID http://orcid.org/0000-0001-6352-9671
M BerrutoIstituto Ortopedico Gaetano Pini, SSD Chirurgia Articolare del Ginocchio, Milan, Italy.
M DentiClinica Luganese, Lugano, Switzerland.
J Espregueira-MendesOrthopaedics Department, Minho University, Minho, Portugal.
J MenetreyCentre de medicine de l'appareil locomoteur et sport, Unité d'Orthopédie et Traumatologie du Sport (UOTS), Service de Chirurgie Orthopédique et Traumatologie de l'appareil moteur, University Hospital of Geneva, Geneva, Switzerland.
G M PerettiIRCCS Istituto Ortopedico Galeazzi, Milan, Italy.
R SeilService de Chirurgie Orthopédique, Centre de L'Appareil Locomoteur, de Médecine du Sport et de Prévention, Centre Hospitalier de Luxembourg-Clinique d'Eich and Sports Medicine Research Laboratory, Luxembourg Institute of Health, 78, rue d'Eich, 1460, Luxembourg, Luxembourg.
G FilardoII Orthopaedic and Traumatologic Clinic - Biomechanics and Technology Innovation Laboratory, Rizzoli Orthopaedic Institute, Bologna, Italy.
Istituto Ortopedico Rizzoli · ITCentre Hospitalier de Luxembourg · LUClinica Luganese Moncucco · CHEspregueira Mendes Clinic · PTIstituto Ortopedico Gaetano Pini · ITUniversity Hospital Coventry · GBUniversity Hospital of Geneva · CHUniversity of Milan · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sports activities are considered favourable for general health; nevertheless, a possible influence of sports practice on the development of early osteoarthritis (OA) is a cause for concern. A higher incidence of OA in knees and ankles of former high-impact sports players than in those of the normal population has been shown and it is still debatable whether the cause is either to be recognized generically in the higher number of injuries or in a joint overload. The possibility to address knee OA in its early phases may be strictly connected to the modification of specific extrinsic or intrinsic factors, related to the patient in order to save the joint from further disease progression; these include sport practice, equipment and load. Non-surgical therapies such as continuative muscles reinforce and training play a strong role in the care of athletes with early OA, particularly if professional. There is an overall agreement on the need of an early restoring of a proper meniscal, ligament and cartilage integrity in order to protect the knee and resume sports safely, whereas alignment is a point still strongly debatable especially for professional athletes. Remaining questions still to be answered are the risks of different sports in relation to one another, although an actual protective effect of low-impact sports, such as walking, swimming or cycling, has been recognized on the appearance or worsening of OA, the effect of continuing or ceasing to practice a sport on the natural history of early OA, and even following appropriate treatment is still unknown.

Indexed as

SportsAthletic InjuriesCartilage, ArticularDisease ProgressionExercise TherapyHumansIncidenceKnee JointOsteoarthritis, KneeCartilageDegenerationEarly osteoarthritisKneeSport

Identifiers

PMID27043343
OpenAlexW2340950431

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.