Trial reportPloS one2016
Heart Rate Variability and Autonomic Modulations in Preeclampsia.
Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Autonomic Dysfunction in Preeclampsia: A Systematic Review.Frontiers in neurology · 2019Pooled it
- VEGF and VEGFR1 levels in different regions of the normal and preeclampsia placentae.Molecular and cellular biochemistry · 2018Trial
- Article
- Postpartum Blood Pressure Variability and Heart Rate Variability in Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2024Article
- Autonomic Dysfunction and Cardiac Performance in Pregnant Women with Hypertensive Disorders: A Comparative Study Using Heart Rate Variability and Global Longitudinal Strain.Life (Basel, Switzerland) · 2024Article
- Editorial: The repercussions of maternal inflammation in pre-eclampsia on fetal health and neurodevelopment.Frontiers in immunology · 2024Article
- Changes in the autonomic cardiorespiratory activity in parturient women with severe and moderate features of preeclampsia.Frontiers in immunology · 2023Article
- Nonlinear analysis of heart rhythm in preeclampsia: a route for translational clinical applications in neuroinflammation.Clinical hypertension · 2021Review
- Heart rate variability and hematological parameters in pregnant women.Journal of clinical laboratory analysis · 2020Article
- Sympathetic nervous system control of vascular function and blood pressure during pregnancy and preeclampsia.Journal of hypertension · 2019Review
- Adrenergic receptor blockade attenuates placental ischemia-induced hypertension.Physiological reports · 2018Article
- Heart Rate Variability and Cardiovascular Reflex Tests for Assessment of Autonomic Functions in Preeclampsia.International journal of hypertension · 2018Article
- Monitoring fetal maturation-objectives, techniques and indices of autonomic function.Physiological measurement · 2017Review
- Maternal Heart Rate Variability during the First Stage of Labor.Frontiers in physiology · 2017Article
- Autonomic imbalance captures maternal and fetal circulatory response to pre-eclampsia.Clinical hypertension · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the exact pathophysiology of preeclampsia is not well understood, autonomic nervous system imbalance is suggested as one of the main factors.
aimsTo investigate heart rate variability (HRV) and autonomic modulations in Sudanese pregnant women with preeclampsia. SUBJECTS AND
methodsA case-control study (60 women in each arm) was conducted at Omdurman Maternity Hospital-Sudan, during the period from June to August, 2014. Cases were women presented with preeclampsia and healthy pregnant women were the controls. Studied groups were matched for important determinants of HRV. Natural logarithm (Ln) of total power (TP), high frequency (HF), low frequency (LF) and very low frequency (VLF) were used to determine HRV. Normalized low and high frequencies (LF Norm and HF Norm) were used to evaluate sympathetic and parasympathetic autonomic modulations respectively.
resultsPatients with preeclampsia achieved significantly higher LF Norm [49.80 (16.25) vs. 44.55 (19.15), P = 0.044] and LnLF/HF [0.04 (0.68) vs. -0.28 (0.91), P = 0.023] readings, but lower HF Norm [49.08 (15.29) vs. 55.87 (19.56), P = 0.012], compared with healthy pregnant women. Although all other HRV measurements were higher in the patients with preeclampsia compared with the controls, only LnVLF [4.50 (1.19) vs. 4.01 (1.06), P = 0.017] and LnLF [4.01 (1.58) vs. 3.49 (1.23), P = 0.040] reached statistical significance.
conclusionThe study adds further evidence for the dominant cardiac sympathetic modulations on patients with preeclampsia, probably secondary to parasympathetic withdrawal in this group. However, the higher LnVLF and LnLF readings achieved by preeclamptic women compared with the controls are unexpected in the view that augmented sympathetic modulations usually depresses all HRV parameters including these two measures.
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