ArticleNature neuroscience2016
A GABAergic nigrotectal pathway for coordination of drinking behavior.
Article in Nature neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03470324 (Combined Stimulation of Subthalamic Nucleus and Substantia Nigra Pars Reticulata for Dysphagia), which is not on this map. Cited by 51 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combined Stimulation of Subthalamic Nucleus and Substantia Nigra Pars Reticulata for Dysphagia: A Randomized Controlled Multicenter Trial
Who cites it
51 citing papers in PubMed.
- Nigral stimulation for freezing of gait: kinematic gait parameters inform optimization of stimulation frequency.Journal of neuroengineering and rehabilitation · 2025Trial
- Oral Transport, Penetration, and Aspiration in PD: Insights from a RCT on STN + SNr Stimulation.Dysphagia · 2025Trial
- Impact of simultaneous subthalamic and nigral stimulation on dysphagia in Parkinson's disease.Annals of clinical and translational neurology · 2020Trial
- Continuous contributions of the dorsolateral striatum to movement initiation and execution.Science advances · 2026Article
- Brainstem Circuits for Rhythm Generation and Coordination of Orofacial Movements.Annual review of neuroscience · 2026Review
- The parafascicular thalamus steers attention to facilitate learning.bioRxiv : the preprint server for biology · 2026Article
- Correlates of head-fixed directional forelimb movements in mouse superior colliculus and substantia nigra pars reticulata.Neuroscience · 2026Article
- Basal ganglia output dynamically controls skilled forelimb kinematics in real time.bioRxiv : the preprint server for biology · 2026Article
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- Aligning brain and behavior.Current opinion in behavioral sciences · 2025Article
- Stimulus selection enhances value-modulated somatosensory processing in the superior colliculus.PLoS biology · 2025Article
- A brainstem map of orofacial rhythms.bioRxiv : the preprint server for biology · 2025Article
- A collicular map for touch-guided tongue control.Nature · 2025Article
- The direct and indirect pathways of the basal ganglia antagonistically influence cortical activity and perceptual decisions.iScience · 2024Article
- Basal ganglia-spinal cord pathway that commands locomotor gait asymmetries in mice.Nature neuroscience · 2024Article
- Simulated Dopamine Modulation of a Neurorobotic Model of the Basal Ganglia.Biomimetics (Basel, Switzerland) · 2024Article
- Article
- Pathways from the Superior Colliculus to the Basal Ganglia.Current neuropharmacology · 2024Review
- Low- and high-level coordination of orofacial motor actions.Current opinion in neurobiology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
The contribution of basal ganglia outputs to consummatory behavior remains poorly understood. We recorded from the substantia nigra pars reticulata (SNR), the major basal ganglia output nucleus, during self-initiated drinking in mice. The firing rates of many lateral SNR neurons were time-locked to individual licks. These neurons send GABAergic projections to the deep layers of the orofacial region of the lateral tectum (superior colliculus, SC). Many tectal neurons were also time-locked to licking, but their activity was usually in antiphase with that of SNR neurons, suggesting inhibitory nigrotectal projections. We used optogenetics to selectively activate the GABAergic nigrotectal afferents in the deep layers of the SC. Photo-stimulation of the nigrotectal projections transiently inhibited the activity of the lick-related tectal neurons, disrupted their licking-related oscillatory pattern and suppressed self-initiated drinking. These results demonstrate that GABAergic nigrotectal projections have a crucial role in coordinating drinking behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.