ArticlePloS one2016
Increased Reactive Oxygen Species Formation and Oxidative Stress in Rheumatoid Arthritis.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers, 5 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
183 citing papers in PubMed, 5 syntheses or guidelines pooled it, 419 citations in OpenAlex.
- Meta-analysis and systematic review: the association between rheumatoid arthritis and the risk of thyroid cancer.Frontiers in immunology · 2026Pooled it
- Pooled it
- Association between maternal rheumatoid arthritis and small for gestational age neonates: a systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- A systematic review of preclinical studies on the efficacy of taurine for the treatment of rheumatoid arthritis.Amino acids · 2021Pooled it
- The Efficacy of Antioxidative Stress Therapy on Oxidative Stress Levels in Rheumatoid Arthritis: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Oxidative medicine and cellular longevity · 2021Pooled it
- Trial
- Trial
- Effects of melatonin supplementation on disease activity, oxidative stress, inflammatory, and metabolic parameters in patients with rheumatoid arthritis: a randomized double-blind placebo-controlled trial.Clinical rheumatology · 2021Trial
- Curcuma longa extract reduces inflammatory and oxidative stress biomarkers in osteoarthritis of knee: a four-month, double-blind, randomized, placebo-controlled trial.Inflammopharmacology · 2016Trial
- Evaluation ofBiology · 2026Article
- Mito-TEMPO improves survival rates inScience advances · 2026Article
- Evaluation of serum antioxidant markers and calcium levels in women with Arthritis.Pakistan journal of medical sciences · 2026Article
- Phytochemical Characterization and Evaluation of Antioxidant, Anti-Inflammatory, Cytotoxic, Genotoxic, and Anti-Arthritic Activities ofPlants (Basel, Switzerland) · 2026Article
- Point-of-care Diagnostic Framework for Fibromyalgia Using Integrated Vibrational Spectroscopy and Metabolomics.Research square · 2026Article
- Amelioration of experimentally induced-arthritis by guaiazulene through targeting inflammatory and oxidative stress biomarkers in Wistar rat.Inflammopharmacology · 2026Article
- Article
- Effects of Pelargonium sidoides root extract on paw oedema, nitric oxide signaling, and synovial vascular changes in a rat model of adjuvant-induced arthritis.Inflammopharmacology · 2026Article
- Article
- A Phycoerythrin-SOD Fluorescent Probe Enables Detection of Oxidative Stress for Assessing Astaxanthin in NAFLD.Antioxidants (Basel, Switzerland) · 2026Article
- Insights Into the HIF-1α-Mediated NLRP3 Pyroptosis Pathway in the Regulation of Musculoskeletal Diseases in the High-Altitude Environment.Journal of inflammation research · 2026Review
123 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRheumatoid arthritis (RA) is an autoimmune inflammatory disorder. Highly reactive oxygen free radicals are believed to be involved in the pathogenesis of the disease. In this study, RA patients were sub-grouped depending upon the presence or absence of rheumatoid factor, disease activity score and disease duration. RA Patients (120) and healthy controls (53) were evaluated for the oxidant-antioxidant status by monitoring ROS production, biomarkers of lipid peroxidation, protein oxidation and DNA damage. The level of various enzymatic and non-enzymatic antioxidants was also monitored. Correlation analysis was also performed for analysing the association between ROS and various other parameters.
methodsIntracellular ROS formation, lipid peroxidation (MDA level), protein oxidation (carbonyl level and thiol level) and DNA damage were detected in the blood of RA patients. Antioxidant status was evaluated by FRAP assay, DPPH reduction assay and enzymatic (SOD, catalase, GST, GR) and non-enzymatic (vitamin C and GSH) antioxidants.
resultsRA patients showed a higher ROS production, increased lipid peroxidation, protein oxidation and DNA damage. A significant decline in the ferric reducing ability, DPPH radical quenching ability and the levels of antioxidants has also been observed. Significant correlation has been found between ROS and various other parameters studied.
conclusionRA patients showed a marked increase in ROS formation, lipid peroxidation, protein oxidation, DNA damage and decrease in the activity of antioxidant defence system leading to oxidative stress which may contribute to tissue damage and hence to the chronicity of the disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.