Evidence map›Paper›PMID 27043077›Full record

ArticleAIDS care2016

Antiretroviral therapy initiation and adherence in rural South Africa: community health workers' perspectives on barriers and facilitators.

Kelsey B Loeliger, Linda M Niccolai, Lillian N Mtungwa, Anthony Moll, Sheela V Shenoi

Registry-linked trialAbstract read
In one paragraph

Article in AIDS care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03438370 (Outcomes of Differentiated Models of Antiretroviral Treatment), which is not on this map. Cited by 37 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03438370 naunknown statusnot on this mapstarted 2017, after this paper: background citation

Outcomes of Differentiated Models of Antiretroviral Treatment (ART) Provision: Multi-Month Dispensing (MMD) of ART in Community ART Distribution for Stable HIV Infected Patients

TypeinterventionalSponsorEquip, LesothoRan2017 to 2019Enrolled5,760ConditionsHIV/AIDSArmsThree monthly ART supply at CAGs, Six monthly ART supply at outreaches
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  9. Observational
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  17. 'We have goals but [it is difficult]'. Barriers to antiretroviral therapy adherence among women using alcohol and other drugs living with HIV in South Africa.Health expectations : an international journal of public participation in health care and health policy · 2022
    Article
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  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Kelsey B Loeligera Section of Infectious Diseases , Yale University School of Medicine , New Haven , CT , USA.
Linda M Niccolaib Department of Epidemiology of Microbial Diseases , Yale University School of Public Health , New Haven , CT , USA.
Lillian N Mtungwac Church of Scotland Hospital , Tugela Ferry , KwaZulu-Natal , South Africa.
Anthony Mollc Church of Scotland Hospital , Tugela Ferry , KwaZulu-Natal , South Africa.
Sheela V Shenoia Section of Infectious Diseases , Yale University School of Medicine , New Haven , CT , USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9M
TRAINING IN THE PATHOGENESIS OF INFECTIOUS DISEASEST32AI007517 · NIAID · YALE UNIVERSITY · PI Jaimie Meyer, Albert C Shaw · 1997 to 2026
$6.1M
Community-Based Intensive Case Finding for HIV, TB, and MDR/XDR TB in Rural SouthK23AI089260 · NIAID · YALE UNIVERSITY · PI SHENOI, SHEELA · 2011 to 2015
$668k
NCATS NIH HHS UL1 TR001863NIAID NIH HHS K23 AI089260NIAID NIH HHS T32 AI007517NIGMS NIH HHS T32 GM007205
6 · The paper itself

Abstract

South Africa has the largest global HIV/AIDS epidemic, but barriers along the HIV care continuum prevent patients from initiating and adhering to antiretroviral therapy (ART). To qualitatively explore reasons for poor ART initiation and adherence rates from the unique perspective of community health workers (CHWs), we conducted focus groups during May-August 2014 with 21 CHWs in rural Msinga, KwaZulu-Natal. Interviews were audio-recorded, transcribed, and translated from Zulu into English. Hybrid deductive and inductive analytical methods were applied to identify emergent themes. Multiple psychosocial, socioeconomic, and socio-medical barriers acted at the level of the individual, social network, broader community, and healthcare environment to simultaneously hinder initiation of and adherence to ART. Key themes included insufficient patient education and social support, patient dissatisfaction with healthcare services, socioeconomic factors, and tension between ART and alternative medicine. Fear of lifelong therapy thwarted initiation whereas substance abuse principally impeded adherence. In conclusion, HIV/AIDS management requires patient counselling and support extending beyond initial diagnosis. Treating HIV/AIDS as a chronic rather than acute infectious disease is key to improving ART initiation and long-term adherence. Public health strategies include expanding CHWs' roles to strengthen healthcare services, provide longitudinal patient support, and foster collaboration with alternative medicine providers.

Indexed as

Health Services AccessibilityMedication AdherenceSocial StigmaTruth DisclosureAnti-HIV AgentsAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveBlack PeopleCommunity Health WorkersCounselingFocus GroupsHIV InfectionsHumansInterviews as TopicLost to Follow-UpMaleAnti-HIV AgentsAnti-Retroviral AgentsadherenceAntiretroviral therapybarriers to carecommunity health workersinitiationSouth Africa

Identifiers

PMID27043077
PMCPMC4917424

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.