Evidence map›Paper›PMID 27043043›Full record

ReviewAnnals of neurology2016

The "neuro" of neuroblastoma: Neuroblastoma as a neurodevelopmental disorder.

Nancy Ratner, Garrett M Brodeur, Russell C Dale, Nina F Schor

Abstract readReview
In one paragraph

Review in Annals of neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
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  3. Article
  4. Ganglioside Profiling Uncovers Distinct Patterns in High-Risk Neuroblastoma.International journal of molecular sciences · 2025
    Article
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  6. Review
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  14. Review
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  18. Multiscale Mechanobiology in Brain Physiology and Diseases.Frontiers in cell and developmental biology · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Nancy RatnerDepartment of Pediatrics, Cincinnati Children's Hospital and University of Cincinnati, Cincinnati, OH.
Garrett M BrodeurDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA.
Russell C DaleClinical School, the Children's Hospital at Westmead, University of Sydney, Sydney, New South Wales, Australia.
Nina F SchorDepartment of Pediatrics, University of Rochester Medical Center, Rochester, NY.
Children's Hospital at Westmead · AUChildren's Hospital of Philadelphia · USUniversity of Cincinnati · USUniversity of Rochester Medical Center · US

Funding

MITOGENIC ACTIVITIES IN NEUROFIBROMATOSISR01NS028840 · NINDS · UNIVERSITY OF CINCINNATI · PI NANCY RATNER · 1990 to 2026
$10.1M
Trk Expression and Inhibition in Human NeuroblastomasR01CA094194 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI BRODEUR, GARRETT M · 2002 to 2012
$3.7M
NEUROTROPHIC MECHANISMS IN NEUROBLASTOMAR01NS038569 · NINDS · UNIVERSITY OF ROCHESTER · PI SCHOR, NINA F · 2000 to 2008
$2.4M
TARGETED THERAPY FOR CHEMORESISTANT TUMORSR01CA074289 · NCI · UNIVERSITY OF ROCHESTER · PI SCHOR, NINA F · 1998 to 2006
$1.6M
NCI NIH HHS R01 CA074289NCI NIH HHS R01 CA094194NINDS NIH HHS R01 NS028840NINDS NIH HHS R01 NS038569
6 · The paper itself

Abstract

Neuroblastoma is a childhood cancer derived from cells of neural crest origin. The hallmarks of its enigmatic character include its propensity for spontaneous regression under some circumstances and its association with paraneoplastic opsoclonus, myoclonus, and ataxia. The neurodevelopmental underpinnings of its origins may provide important clues for development of novel therapeutic and preventive agents for this frequently fatal malignancy and for the associated paraneoplastic syndromes. Ann Neurol 2016;80:13-23.

Indexed as

Disease ProgressionHumansMolecular Targeted TherapyNeoplasm Regression, SpontaneousNeural CrestNeuroblastomaNeurodevelopmental DisordersOpsoclonus-Myoclonus SyndromeParaneoplastic Syndromes, Nervous System

Identifiers

PMID27043043
PMCPMC5419586
OpenAlexW2339231326

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.