ReviewContinuum (Minneapolis, Minn.)2016
Diagnosis and Treatment of Idiopathic Normal Pressure Hydrocephalus.
Review in Continuum (Minneapolis, Minn.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 124 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Intradural Percutaneous Stimulation - Inducing Physiological Responses.
The Role of the Glymphatic System Avaluated Thourgh mr Imaging in the Diagnosis and Management of NPH
Who cites it
124 citing papers in PubMed, 4 syntheses or guidelines pooled it, 266 citations in OpenAlex.
- Cervical epidural venous engorgement after cerebrospinal fluid shunting: clinical-radiological correlation and systematic review.Neurosurgical review · 2026Pooled it
- Prognostic Utility of Disproportionately Enlarged Subarachnoid Space Hydrocephalus in Idiopathic Normal Pressure Hydrocephalus Treated with Ventriculoperitoneal Shunt Surgery: A Systematic Review and Meta-analysis.AJNR. American journal of neuroradiology · 2021Pooled it
- Diagnostic performance and interobserver agreement of the callosal angle and Evans' index in idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis.European radiology · 2021Pooled it
- Guidelines for Management of Idiopathic Normal Pressure Hydrocephalus (Third Edition): Endorsed by the Japanese Society of Normal Pressure Hydrocephalus.Neurologia medico-chirurgica · 2021Guideline
- The clinical trials landscape of hydrocephalus: a scoping review of therapeutic priorities, innovation trends, and research gaps.Neurosurgical review · 2026Article
- Neonatal cerebral hemodynamics under elevated intracranial pressure: a near-infrared spectroscopy study in piglets.Pediatric research · 2026Article
- MRI-based cerebrospinal fluid volumetric indices for predicting tap test response in idiopathic normal pressure hydrocephalus.Radiological physics and technology · 2026Observational
- Comparison of Anterior Lateral Ventricular Index with Evans Index, Callosal Angle, and Disproportionately Enlarged Subarachnoid-space Hydrocephalus in Postoperative Evaluation of Idiopathic Normal Pressure Hydrocephalus.Neurologia medico-chirurgica · 2026Article
- Clinical and Radiological Evolution of Idiopathic Normal Pressure Hydrocephalus: A Critical Review.Movement disorders clinical practice · 2026Review
- Distinct Clinical Phenotypes of Infection and Mechanical Dysfunction in Ventriculoperitoneal Shunt Complications.Cureus · 2026Article
- Normal pressure hydrocephalus plus atypical presentation with symptomatic resolution following the restoration of CSF flow: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Assessing CT-based volumetric analysis via deep learning for idiopathic normal pressure hydrocephalus.Brain communications · 2026Article
- Lumbar puncture seems to be safe and practical ın oldest-old patients: a protocol from a memory center.European geriatric medicine · 2025Article
- Age at time of surgery does not influence outcome in idiopathic normal pressure hydrocephalus - a national quality registry study of 3082 patients.Acta neurochirurgica · 2025Article
- Article
- Implications of the glymphatic system in the diagnostic and surgical workup of normal pressure hydrocephalus.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Beyond the triad: akinetic mutism in idiopathic normal pressure hydrocephalus, with response to shunt placement. Illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Time Course of Symptoms in Normal-Pressure Hydrocephalus: A Systematic Review.Diagnostics (Basel, Switzerland) · 2025Review
- Reversal of cerebral pseudoatrophy in normal pressure hydrocephalus after ventriculoatrial shunt placement.Scientific reports · 2025Article
- Value of biomarkers in the prediction of shunt responsivity in patients with normal pressure hydrocephalus.Neurosurgical review · 2025Observational
64 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purpose of reviewThis article provides neurologists with a pragmatic approach to the diagnosis and treatment of idiopathic normal pressure hydrocephalus (iNPH), including an overview of: (1) key symptoms and examination and radiologic findings; (2) use of appropriate tests to determine the patient's likelihood of shunt responsiveness; (3) appropriate referral to tertiary centers with expertise in complex iNPH; and (4) the contribution of neurologists to the care of patients with iNPH following shunt surgery. RECENT
findingsThe prevalence of iNPH is higher than previously estimated; however, only a fraction of persons with the disorder receive shunt surgery. iNPH should be considered as a diagnosis for patients with unexplained symmetric gait disturbance, a frontal-subcortical pattern of cognitive impairment, and urinary urge incontinence, whose MRI scans show enlarged ventricles and whose comorbidities are not sufficient to explain their symptoms. Physiologically based tests, such as the tap test (large-volume lumbar puncture) or temporary spinal catheter insertion for external lumbar drainage with gait testing before and after CSF removal, or CSF infusion testing for measurement of CSF outflow resistance, can reliably identify patients who are likely to respond to shunt surgery. Properly selected patients have an 80% to 90% chance of responding to shunt surgery, and all symptoms can improve following shunt surgery. Longitudinal care involves investigating the differential diagnosis of any symptoms that either fail to respond to shunt surgery or that worsen after initial improvement from shunt surgery. SUMMARY: Neurologists play an important role in the identification of patients who should be evaluated for possible iNPH. With contemporary diagnostic tests and treatment with programmable shunts, the benefit-to-risk ratio of shunt surgery is highly favorable. For more complex patients, tertiary centers with expertise in complex iNPH are available throughout the world.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.