Trial reportPloS one2016
Salivary Melatonin in Relation to Depressive Symptom Severity in Young Adults.
Trial report in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Allostatic and Circadian Drives in Patients with Bipolar Disorder in Depressive Episodes or with Post-Traumatic Stress Disorder Versus Healthy Controls: Neuroendocrine Comparison Through Cortisol and 6-Sulfatoxymelatonin Overnight Urine Excretion.International journal of molecular sciences · 2026Article
- Thermoregulation in Sleep Disorders-Comprehensive Review.Journal of clinical medicine · 2026Review
- Detailed Review of Melatonin and its Role in Managing the Symptoms of Depression.Current molecular medicine · 2026Review
- Chronotherapeutic Treatments for Psychiatric Disorders: A Narrative Review of Recent Literature.Current psychiatry reports · 2025Review
- Salivary hormones in depression: the future in diagnosis and treatment.Annals of general psychiatry · 2025Review
- Social disadvantage is associated with impaired increase in salivary diurnal melatonin amplitude throughout pregnancy.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Melatonin rhythm disorder is more pronounced in major depressive disorder with non-suicidal self-injury.Frontiers in neuroscience · 2025Article
- Serum melatonin levels in type 2 diabetic patients with depressive symptoms compared to non-depressed individuals.Caspian journal of internal medicine · 2024Article
- Assessment of sleep quality and its factors among clinicians working in critical care units and operation theaters at North West Ethiopia, 2022: a multicenter cross-sectional study.Annals of medicine and surgery (2012) · 2023Article
- Can melatonin reduce the severity of post-COVID-19 syndrome?EXCLI journal · 2023Review
- Tryptophan metabolites in depression: Modulation by gut microbiota.Frontiers in behavioral neuroscience · 2022Review
- Associations between Melatonin, Neuroinflammation, and Brain Alterations in Depression.International journal of molecular sciences · 2021Review
- Antidepressants and Circadian Rhythm: Exploring Their Bidirectional Interaction for the Treatment of Depression.Pharmaceutics · 2021Review
- Biological Markers in Anxiety Disorders.Journal of clinical medicine · 2021Review
- Salivary Biomarkers of Stress, Anxiety and Depression.Journal of clinical medicine · 2021Review
- Pruritus, Allergy and Autoimmunity: Paving the Way for an Integrated Understanding of Psychodermatological Diseases?Frontiers in allergy · 2021Article
- Melatonin and Depression: A Translational Perspective From Animal Models to Clinical Studies.Frontiers in psychiatry · 2021Review
- Associations of Electronic Device Use Before and After Sleep With Psychological Distress Among Chinese Adults in Hong Kong: Cross-Sectional Study.JMIR mental health · 2020Article
- Melatonin Modulates Dendrite Maturation and Complexity in the Dorsal- and Ventral- Dentate Gyrus Concomitantly with Its Antidepressant-Like Effect in Male Balb/C Mice.International journal of molecular sciences · 2020Article
- The Relationship Between Daytime Salivary Melatonin and Gastrointestinal Symptoms in Young Adults Seeking Psychiatric Care.Psychosomatic medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reduced levels of melatonin have been associated with severe depression. The aim was to investigate the correlation between salivary melatonin and dimensional measures of depressive symptom severity in young adult psychiatric patients. Levels of melatonin were analyzed in six saliva samples during waking hours from 119 young adult patients under outpatient psychiatric care. Melatonin levels were tested for association with the severity of depressive symptoms using the self-rating version of the Montgomery Åsberg Depression Rating Scale (MADRS-S). Where possible, depressive symptoms were assessed again after 6±2 months of treatment. Response was defined as decrease in MADRS-S by ≥50% between baseline and follow-up. Patients with levels of melatonin in the lowest quartile at bedtime had an increased probability of a high MADRS-S score compared to those with the highest levels of melatonin (odds ratio 1.39, 95% CI 1.15-1.69, p<0.01). A post hoc regression analysis found that bedtime melatonin levels predicted response (odds ratio 4.4, 95% CI 1.06-18.43, p<0.05). A negative relationship between salivary melatonin and dimensional measures of depressive symptom severity was found in young patients under outpatient psychiatric care. Bedtime salivary melatonin levels may have prognostic implications.
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