Evidence map›Paper›PMID 27042843›Full record

ArticleBone marrow transplantation2016

Factors influencing the late phase of recovery after bone mineral density loss in allogeneic stem cell transplantation survivors.

P Anandi, N A Jain, X Tian, C O Wu, P A Pophali, E Koklanaris, S Ito, B N Savani, J Barrett, M Battiwalla

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Review
  7. Observational
  8. Article
  9. Article
  10. Bone management in hematologic stem cell transplant recipients.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018
    Review
  11. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

P AnandiHematology Branch, NHLBI, NIH, Bethesda, MD, USA.
N A JainHematology Branch, NHLBI, NIH, Bethesda, MD, USA.
X TianOffice of Biostatistics Research, NHLBI, NIH, Bethesda, MD, USA.
C O WuOffice of Biostatistics Research, NHLBI, NIH, Bethesda, MD, USA.
P A PophaliHematology Branch, NHLBI, NIH, Bethesda, MD, USA.
E KoklanarisHematology Branch, NHLBI, NIH, Bethesda, MD, USA.
S ItoHematology Branch, NHLBI, NIH, Bethesda, MD, USA.
B N SavaniVanderbilt University Medical Center, Nashville, TN, USA.
J BarrettHematology Branch, NHLBI, NIH, Bethesda, MD, USA.
M BattiwallaHematology Branch, NHLBI, NIH, Bethesda, MD, USA.
National Heart Lung and Blood Institute · USNational Institutes of Health · USCancer Research And Biostatistics · USVanderbilt University Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accelerated bone mineral density loss (BMDL) occurs early after allogeneic stem cell transplantation (SCT) and is related to factors such as steroids and chronic GvHD. In order to understand the natural history of BMDL of SCT in the longer term, we evaluated a longitudinal cohort of 148 survivors with a median follow-up of 12 years (range 3-22 years). All women received hormone replacement therapy, and routine calcium/vitamin D supplementation was recommended but ∼50% of patients still had suboptimal vitamin D levels and bisphosphonates were rarely utilized. BMD significantly improved from 5 to 20+ years but the femoral neck and forearm remained vulnerable sites. Younger age, higher pretransplant body mass index (BMI) and increment in BMI post transplant were significantly associated with increased BMD and protected against osteopenia/osteoporosis. These findings support consideration of BMD loss in SCT survivors in two phases, an early phase of BMD loss (3-5 years) followed by a later phase of BMD recovery, with different protective and aggravating factors. Treatment- and transplant-related factors (such as steroids, immunosuppressives, chronic GvHD, vitamin D) are known to impact the early phase of BMD loss but age and BMI are more influential in the late phase of BMD recovery.

Indexed as

SurvivorsAdolescentAdultAgedBone DensityChildDiphosphonatesFemaleFemur NeckForearmHormone Replacement TherapyHumansLongitudinal StudiesMaleMiddle AgedOsteoporosisDiphosphonatesVitamin D

Identifiers

PMID27042843
OpenAlexW2339429434

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.