Evidence map›Paper›PMID 27042834›Full record

ArticleBone marrow transplantation2016

Development, preliminary usability and accuracy testing of the EBMT 'eGVHD App' to support GvHD assessment according to NIH criteria-a proof of concept.

H Schoemans, K Goris, R V Durm, J Vanhoof, D Wolff, H Greinix, S Pavletic, S J Lee, J Maertens, S D Geest and 2 more

Abstract readEvaluation Study
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Modern-Era Challenges in the Clinical Management of Graft-Versus-Host Disease.Advances in experimental medicine and biology · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Challenges in Conducting Studies in Chronic Graft-Clinical hematology international · 2019
    Review
  14. Article
  15. Article
  16. Design Thinking in Health Care.Preventing chronic disease · 2018
    Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

H SchoemansDepartment of Hematology, University Hospital Leuven, KU Leuven, Leuven, Belgium.
K GorisDepartment of Hematology, University Hospital Leuven, KU Leuven, Leuven, Belgium.
R V DurmDepartment of Information Technology, University Hospital Leuven, KU Leuven, Leuven, Belgium.
J VanhoofAcademic Centre for Nursing and Midwifery, University of Leuven, Leuven, Belgium.
D WolffDepartment of Internal Medicine III, Hematology and Oncology, University Medical Center of Regensburg, Regensburg, Germany.
H GreinixDivision of Hematology, Medical University of Graz, Graz, Austria.
S PavleticCenter for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
S J LeeClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
J MaertensDepartment of Hematology, University Hospital Leuven, KU Leuven, Leuven, Belgium.
S D GeestAcademic Centre for Nursing and Midwifery, University of Leuven, Leuven, Belgium.
F DobbelsAcademic Centre for Nursing and Midwifery, University of Leuven, Leuven, Belgium.
R F DuarteHospital Universitario Puerta de Hierro Majadahonda, Calle Joaquín Rodrigo 2, Majadahonda, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The EBMT Complications and Quality of Life Working Party has developed a computer-based algorithm, the 'eGVHD App', using a user-centered design process. Accuracy was tested using a quasi-experimental crossover design with four expert-reviewed case vignettes in a convenience sample of 28 clinical professionals. Perceived usefulness was evaluated by the technology acceptance model (TAM) and User satisfaction by the Post-Study System Usability Questionnaire (PSSUQ). User experience was positive, with a median of 6 TAM points (interquartile range: 1) and beneficial median total, and subscale PSSUQ scores. The initial standard practice assessment of the vignettes yielded 65% correct results for diagnosis and 45% for scoring. The 'eGVHD App' significantly increased diagnostic and scoring accuracy to 93% (+28%) and 88% (+43%), respectively (both P<0.05). The same trend was observed in the repeated analysis of case 2: accuracy improved by using the App (+31% for diagnosis and +39% for scoring), whereas performance tended to decrease once the App was taken away. The 'eGVHD App' could dramatically improve the quality of care and research as it increased the performance of the whole user group by about 30% at the first assessment and showed a trend for improvement of individual performance on repeated case evaluation.

Indexed as

AlgorithmsDiagnosis, Computer-AssistedGraft vs Host DiseaseHumansPredictive Value of TestsQuality of LifeReproducibility of ResultsSurveys and Questionnaires

Identifiers

PMID27042834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.