ArticleRevista brasileira de ortopedia
VISCOSUPPLEMENTATION.
Article in Revista brasileira de ortopedia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Viscosupplementation in patients with severe osteoarthritis of the knee: six month follow-up of a randomized, double-blind clinical trial.International orthopaedics · 2017Trial
- Bioactive-RichBiomedicines · 2026Article
- Intra-articular treatments for hindfoot osteoarthritis.World journal of orthopedics · 2025Article
- Current trends in the treatment of focal cartilage lesions: a comprehensive review.EFORT open reviews · 2025Review
- Comparison of Four Treatment Protocols with Intra-Articular Medium Molecular Weight Hyaluronic Acid in Induced Temporomandibular Osteoarthritis: An Experimental Study.International journal of molecular sciences · 2023Article
- Perinatal Tissue-Derived Allografts and Stromal Cells for the Treatment of Knee Osteoarthritis: A Review of Preclinical and Clinical Evidence.Cartilage · 2022Review
- Natural Compounds Affecting Inflammatory Pathways of Osteoarthritis.Antioxidants (Basel, Switzerland) · 2022Review
- Severe Acute Localized Reactions Following Intra-Articular Hyaluronic Acid Injections in Knee Osteoarthritis.Cartilage · 2021Article
- Effects of low and high molecular weight hyaluronic acid on the osteoarthritic temporomandibular joint in rabbit.Clinical oral investigations · 2021Article
- A Comprehensive Review of Viscosupplementation in Osteoarthritis of the Knee.Orthopedic reviews · 2021Review
- Synovial fluid lubricin and hyaluronan are altered in equine osteochondral fragmentation, cartilage impact injury, and full-thickness cartilage defect models.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Minimally Invasive Treatment of Chronic Ankle Instability: a Comprehensive Review.Current pain and headache reports · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
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Abstract
With the aging of the world's population, the prevalence of age-related diseases is continually increasing, especially osteoarthritis, the most common form of joint disease. In addition to its high prevalence, osteoarthritis has been correlated with high medical and social costs. Among the treatment methods, viscosupplementation (intra-articular injection of hyaluronic acid derivatives) has been gaining more prominence. The substances used are high molecular weight polysaccharides that, in addition to mechanical functions of weight distribution and joint lubrication, have anti-inflammatory properties and physical-chemical action on a variety of joint characteristics. These effects are directly proportional to the molecular weight and concentration of the drug used and any cross-links that may be present in the drug. Viscosupplementation is a simple procedure and can be performed in outpatient clinics. It provides benefits regarding pain and function, and also favorably alters the course of the disease, through quantitatively and qualitatively improving the joint cartilage. It has a good safety profile and favorable cost-effectiveness relationship, and is indicated both for osteoarthritis cases and after an arthroscopic procedure.
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Registered trials
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