ArticleNeural plasticity2016
Human Auditory and Adjacent Nonauditory Cerebral Cortices Are Hypermetabolic in Tinnitus as Measured by Functional Near-Infrared Spectroscopy (fNIRS).
Article in Neural plasticity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 34 citations in OpenAlex.
- Motivational Coaching Cues Can Modulate Prefrontal Cortex Activity and Perceptual Responses of Elite Football Players During High-Intensity Interval Training: A Randomised Crossover fNIRS Study.European journal of sport science · 2026Trial
- Association Between Tinnitus and Angina Pectoris in U.S. Adults: Evidence from NHANES 2009-2018.Audiology research · 2026Article
- Unpleasant odors compared to pleasant ones cause higher cortical activations detectable by fNIRS and observable mostly in females.APL bioengineering · 2025Article
- A narrative review of functional near-infrared spectroscopy (fNIRS) applications in hearing loss, tinnitus and vestibular disorders.Frontiers in neuroscience · 2025Review
- Predicting Individual Response to Acupuncture in Sensorineural Tinnitus Using Integrated Functional Near-Infrared Spectroscopy and Machine Learning: Protocol for a Model Development and Validation Study.Journal of multidisciplinary healthcare · 2025Article
- Application of functional near-infrared spectroscopy (fNIRS) in tinnitus research: contemporary insights and perspectives.Frontiers in psychology · 2024Article
- Differential cortical activation patterns: pioneering sub-classification of tinnitus with and without hyperacusis by combining audiometry, gamma oscillations, and hemodynamics.Frontiers in neuroscience · 2023Article
- Evaluating the Efficacy and Underlying Mechanisms of Acupuncture for Chronic Subjective Tinnitus Using Functional Near-Infrared Spectroscopy: Study Protocol for a Randomized Controlled Trial.Journal of pain research · 2023Article
- Comparison of functional activation responses from the auditory cortex derived using multi-distance frequency domain and continuous wave near-infrared spectroscopy.Neurophotonics · 2021Article
- Tinnitus and auditory cortex; Using adapted functional near-infrared-spectroscopy to expand brain imaging in humans.Laryngoscope investigative otolaryngology · 2021Article
- Tinnitus and auditory cortex: using adapted functional near-infrared spectroscopy to measure resting-state functional connectivity.Neuroreport · 2021Article
- Notched Sound Alleviates Tinnitus by Reorganization Emotional Center.Frontiers in human neuroscience · 2021Article
- Objective measurement of tinnitus using functional near-infrared spectroscopy and machine learning.PloS one · 2020Article
- Cortical Activation Patterns of Different Masking Noises and Correlation With Their Masking Efficacy, Determined by Functional Near-Infrared Spectroscopy.Frontiers in human neuroscience · 2020Article
- Functional Near-Infrared Spectroscopy to Probe tDCS-Induced Cortical Functioning Changes in Tinnitus.The journal of international advanced otology · 2019Article
- Human central auditory plasticity: A review of functional near-infrared spectroscopy (fNIRS) to measure cochlear implant performance and tinnitus perception.Laryngoscope investigative otolaryngology · 2018Review
- Cortical activation patterns to spatially presented pure tone stimuli with different intensities measured by functional near-infrared spectroscopy.Human brain mapping · 2018Article
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- Expressions of ion co-transporter genes in salicylate-induced tinnitus and treatment effects of spirulina.BMC neurology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Tinnitus is the phantom perception of sound in the absence of an acoustic stimulus. To date, the purported neural correlates of tinnitus from animal models have not been adequately characterized with translational technology in the human brain. The aim of the present study was to measure changes in oxy-hemoglobin concentration from regions of interest (ROI; auditory cortex) and non-ROI (adjacent nonauditory cortices) during auditory stimulation and silence in participants with subjective tinnitus appreciated equally in both ears and in nontinnitus controls using functional near-infrared spectroscopy (fNIRS). Control and tinnitus participants with normal/near-normal hearing were tested during a passive auditory task. Hemodynamic activity was monitored over ROI and non-ROI under episodic periods of auditory stimulation with 750 or 8000 Hz tones, broadband noise, and silence. During periods of silence, tinnitus participants maintained increased hemodynamic responses in ROI, while a significant deactivation was seen in controls. Interestingly, non-ROI activity was also increased in the tinnitus group as compared to controls during silence. The present results demonstrate that both auditory and select nonauditory cortices have elevated hemodynamic activity in participants with tinnitus in the absence of an external auditory stimulus, a finding that may reflect basic science neural correlates of tinnitus that ultimately contribute to phantom sound perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.