ArticleChinese medicine2016
Apoptosis-inducing effects of jujube (Zǎo) seed extracts on human Jurkat leukemia T cells.
Article in Chinese medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Effects of Ziziphus jujuba, metformin, and myoinositol on pregnancy rates and metabolic parameters in infertile women with PCOS: a randomized controlled trial.Journal of ovarian research · 2026Trial
- Postharvest Handling and Storage Strategies for Preserving Jujube (Foods (Basel, Switzerland) · 2025Review
- Review: performance of jujube and its extracts in cancer: therapeutic, toxicity-reducing and potentiating effects.Frontiers in oncology · 2025Review
- A Literature Review of the Pharmacological Effects of Jujube.Foods (Basel, Switzerland) · 2024Review
- Anticancer effects of herbal medicine Emelia-M, Mshikazi and Delosma H against human leukaemia cells.African health sciences · 2023Article
- Mechanism of Jujube (Contrast media & molecular imaging · 2022Article
- Article
- Antioxidant, antimicrobial, and cytotoxic activities of extracts from the seed and pulp of Jujube (Food science & nutrition · 2021Article
- Antiproliferative and Pro-apoptotic Activities ofIranian journal of pharmaceutical research : IJPRArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundJujube (Zǎo) seeds exhibited anticancer effects and used in Chinese medicine for many years. This study aims to investigate the apoptosis-inducing effects of seed extracts from eight different cultivated species ('Apple', 'Bombay', 'Jumbo', 'Kaew', 'Nomsod', 'Rianthong', 'Samros', and 'Taiwan') on human Jurkat leukemia T cells.
methodsWe evaluated the effects of seed extracts from eight jujube cultivated species on human Jurkat leukemia T cells. The crude seed extracts were prepared sequentially by using water, 95 % ethanol, dichloromethane, ethyl acetate, chloroform or hexane. The antiproliferative effects of the jujube seed extracts relative to that of melphalan were evaluated by neutral red assays. Apoptotic cell death induced by the ethanolic extracts at 1 × IC50 and 2 × IC50 concentrations was demonstrated by DAPI staining, gel electrophoresis, flow cytometry with Annexin V/propidium iodide staining, and caspase-3, -8, and -9 enzyme activities.
resultsEthanolic extracts of 'Taiwan', 'Jumbo', 'Nomsod', 'Rianthong', 'Samros', and 'Bombay', significantly inhibited the proliferation of Jurkat cells compared with untreated cells (all P < 0.001), while the extracts of 'Kaew' and 'Apple' were inactive. The six active extracts preferentially induced apoptotic cell death in a concentration-dependent manner with DNA fragmentation (2 × IC50). Increased caspase-3 activity was detected after treatment with the six extracts. The 'Taiwan', 'Nomsod', 'Jumbo', and 'Rianthong' extracts (2 × IC50) induced both the extrinsic and intrinsic apoptosis pathways by increasing caspase-8 and caspase-9 activity, respectively. Alkaloids (Dragendorff's method) and reducing sugars (Fehling's test) were mainly identified in the apoptosis-inducing extracts.
conclusionsThe tested of six active extracts ('Taiwan', 'Jumbo', 'Nomsod', 'Rianthong', 'Samros' and 'Bombay') contained alkaloids or reducing sugars, and induced caspase-dependent apoptosis in human Jurkat leukemia T cells.
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