Evidence map›Paper›PMID 27042182›Full record

ReviewStem cells international2016

Muscle Satellite Cells: Exploring the Basic Biology to Rule Them.

Camila F Almeida, Stephanie A Fernandes, Antonio F Ribeiro Junior, Oswaldo Keith Okamoto, Mariz Vainzof

Abstract readReview
In one paragraph

Review in Stem cells international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  6. Article
  7. Article
  8. Article
  9. Article
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  12. Article
  13. Lemon Myrtle (Nutrients · 2022
    Article
  14. Telocytes: An Emerging Component of Stem Cell Niche Microenvironment.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021
    Review
  15. Review
  16. Cells · 2021
    Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Camila F AlmeidaHuman Genome and Stem Cell Research Center, IBUSP, Rua do Matão 106, Cidade Universitária, 5508-900 São Paulo, SP, Brazil.
Stephanie A FernandesHuman Genome and Stem Cell Research Center, IBUSP, Rua do Matão 106, Cidade Universitária, 5508-900 São Paulo, SP, Brazil.
Antonio F Ribeiro JuniorHuman Genome and Stem Cell Research Center, IBUSP, Rua do Matão 106, Cidade Universitária, 5508-900 São Paulo, SP, Brazil.
Oswaldo Keith OkamotoHuman Genome and Stem Cell Research Center, IBUSP, Rua do Matão 106, Cidade Universitária, 5508-900 São Paulo, SP, Brazil.ORCID 0000-0002-8528-6225
Mariz VainzofHuman Genome and Stem Cell Research Center, IBUSP, Rua do Matão 106, Cidade Universitária, 5508-900 São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult skeletal muscle is a postmitotic tissue with an enormous capacity to regenerate upon injury. This is accomplished by resident stem cells, named satellite cells, which were identified more than 50 years ago. Since their discovery, many researchers have been concentrating efforts to answer questions about their origin and role in muscle development, the way they contribute to muscle regeneration, and their potential to cell-based therapies. Satellite cells are maintained in a quiescent state and upon requirement are activated, proliferating, and fusing with other cells to form or repair myofibers. In addition, they are able to self-renew and replenish the stem pool. Every phase of satellite cell activity is highly regulated and orchestrated by many molecules and signaling pathways; the elucidation of players and mechanisms involved in satellite cell biology is of extreme importance, being the first step to expose the crucial points that could be modulated to extract the optimal response from these cells in therapeutic strategies. Here, we review the basic aspects about satellite cells biology and briefly discuss recent findings about therapeutic attempts, trying to raise questions about how basic biology could provide a solid scaffold to more successful use of these cells in clinics.

Identifiers

PMID27042182
PMCPMC4794588

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.