ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2016
Genistein treatment increases bone mass in obese, hyperglycemic mice.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Estrogen Deficiency in Menopause: A Major Contributor to Cartilage Degeneration and Osteoarthritis: A Systematic Review and Meta-Analysis.Journal of menopausal medicine · 2026Review
- Genistein Suppresses IL-6 and MMP-13 to Attenuate Osteoarthritis in Obese Diabetic Mice.Metabolites · 2023Article
- Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model.Drug design, development and therapy · 2020Article
- Genistein prevents bone loss in type 2 diabetic rats induced by streptozotocin.Food & nutrition research · 2020Article
- Bone Strength Is Improved with Genistein Treatment in Mice with Diet-Induced Obesity.Current developments in nutrition · 2019Article
- Leptin-deficient mice have altered three-dimensional growth plate histomorphometry.Diabetology & metabolic syndrome · 2019Article
- High-fat, high-sugar diet induces splenomegaly that is ameliorated with exercise and genistein treatment.BMC research notes · 2018Article
- Genistein treatment improves fracture resistance in obese diabetic mice.BMC endocrine disorders · 2017Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity and type 2 diabetes mellitus are associated with elevated risk of limb bone fracture. Incidences of these conditions are on the rise worldwide. Genistein, a phytoestrogen, has been shown by several studies to demonstrate bone-protective properties and may improve bone health in obese type 2 diabetics.
methodsIn this study, we test the effects of genistein treatment on limb bone and growth plate cartilage histomorphometry in obese, hyperglycemic ob/ob mice. Six-week-old ob/ob mice were divided into control and genistein-treated groups. Genistein-treated mice were fed a diet containing 600 mg genistein/kg for a period of 4 weeks. Cross-sectional geometric and histomorphometric analyses were conducted on tibias.
resultsGenistein-treated mice remained obese and hyperglycemic. However, histomorphometric comparisons show that genistein-treated mice have greater tibial midshaft diameters and ratios of cortical bone to total tissue area than the controls. Genistein-treated mice also exhibit decreased growth plate thickness of the proximal tibia.
conclusionOur results indicate that genistein treatment affects bone of the tibial midshaft in the ob/ob mouse, independent of improvements in the hyperglycemic state and body weight.
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