ArticleOncoTargets and therapy2016
Prognostic role of hypoxia-inducible factor-1 alpha expression in osteosarcoma: a meta-analysis.
Article in OncoTargets and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinicopathological and prognostic value of hypoxia-inducible factor-1α in patients with bone tumor: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2019Pooled it
- Depleting HIF‑1α attenuates the progression of osteosarcoma, but tumorigenicity is sustained through HIF‑independent pathways.Oncology reports · 2026Article
- Molecular Crosstalk Between RUNX2 and HIF-1α in Osteosarcoma: Implications for Angiogenesis, Metastasis, and Therapy Resistance.International journal of molecular sciences · 2025Review
- Review
- Multi-Anticancer Activities of Phytoestrogens in Human Osteosarcoma.International journal of molecular sciences · 2023Review
- Hypoxia-Inducible Factor-2α Signaling in the Skeletal System.JBMR plus · 2023Review
- KCNJ2/HIF1α positive-feedback loop promotes the metastasis of osteosarcoma.Cell communication and signaling : CCS · 2023Article
- Article
- Hypoxia stimulates the migration and invasion of osteosarcoma via up-regulating the NUSAP1 expression.Open medicine (Warsaw, Poland) · 2021Article
- Distinct roles for the hypoxia-inducible transcription factors HIF-1α and HIF-2α in human osteoclast formation and function.Scientific reports · 2020Article
- A lineage-tracing tool to map the fate of hypoxic tumour cells.Disease models & mechanisms · 2020Article
- New Insights about the Wnt/β-Catenin Signaling Pathway in Primary Bone Tumors and Their Microenvironment: A Promising Target to Develop Therapeutic Strategies?International journal of molecular sciences · 2019Review
- Prognostic Role of Hypoxia-Inducible Factor-2α Tumor Cell Expression in Cancer Patients: A Meta-Analysis.Frontiers in oncology · 2018Article
- Tetrahydrocurcumin induces mesenchymal-epithelial transition and suppresses angiogenesis by targeting HIF-1α and autophagy in human osteosarcoma.Oncotarget · 2017Article
- The effect of pathological fractures on the prognosis of patients with osteosarcoma: a meta-analysis of 14 studies.Oncotarget · 2017Article
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Authors and funding
8 authors.
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Abstract
backgroundHypoxia-inducible factor-1α (HIF-1α) plays an important role in tumor progression and metastasis. A number of studies have investigated the association of HIF-1α with prognosis and clinicopathological characteristics of osteosarcoma but yielded inconsistent results.
methodSystematic computerized searches were performed in PubMed, Embase, and Web of Science databases for relevant original articles. The pooled hazard ratios (HRs) and odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated to assess the prognostic value of HIF-1α expression. The standard mean difference was used to analyze the continuous variable.
resultsFinally, nine studies comprising 486 patients were subjected to final analysis. Protein expression level of HIF-1α was found to be significantly related to overall survival (HR =3.0; 95% CI: 1.46-6.15), disease-free survival (HR =2.23; 95% CI: 1.26-3.92), pathologic grade (OR =21.33; 95% CI: 4.60-98.88), tumor stage (OR =10.29; 95% CI: 3.55-29.82), chemotherapy response (OR =9.68; 95% CI: 1.87-50.18), metastasis (OR =5.06; 95% CI: 2.87-8.92), and microvessel density (standard mean difference =2.83; 95% CI: 2.28-3.39).
conclusionThis meta-analysis revealed that overexpression of HIF-1α is a predictive factor of poor outcomes for osteosarcoma. HIF-1α appeared to play an important role in prognostic evaluation and may be a potential target in antitumoral therapy.
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