Evidence map›Paper›PMID 27042038›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2016

Incidence and outcomes of patients hospitalized with COPD exacerbation with and without pneumonia.

Mette Søgaard, Morten Madsen, Anders Løkke, Ole Hilberg, Henrik Toft Sørensen, Reimar W Thomsen

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Article in International journal of chronic obstructive pulmonary disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  7. Review
  8. Article
  9. Prediction Score ofInternational journal of chronic obstructive pulmonary disease · 2026
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  11. Impact of an Inpatient COPD Care Pathway on Hospital Care Process and Outcome Metrics.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2025
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  12. Article
  13. The Burden of COPD with Type 2 Inflammation in North-West Continental Europe.International journal of chronic obstructive pulmonary disease · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mette SøgaardDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus C, Denmark.
Morten MadsenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus C, Denmark.
Anders LøkkeDepartment of Respiratory Medicine, Aarhus University Hospital, Aarhus C, Denmark.
Ole HilbergDepartment of Respiratory Medicine, Aarhus University Hospital, Aarhus C, Denmark.
Henrik Toft SørensenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus C, Denmark.
Reimar W ThomsenDepartment of Clinical Epidemiology, Aarhus University Hospital, Aarhus C, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPneumonia may be a major contributor to hospitalizations for chronic obstructive pulmonary disease (COPD) exacerbation and influence their outcomes.

methodsWe examined hospitalization rates, health resource utilization, 30-day mortality, and risk of subsequent hospitalizations for COPD exacerbations with and without pneumonia in Denmark during 2006-2012.

resultsWe identified 179,759 hospitalizations for COPD exacerbations, including 52,520 first-time hospitalizations (29.2%). Pneumonia was frequent in first-time exacerbations (36.1%), but declined in successive exacerbations to 25.6% by the seventh or greater exacerbation. Pneumonic COPD exacerbations increased 20% from 0.92 per 1,000 population in 2006 to 1.10 per 1,000 population in 2012. Nonpneumonic exacerbations decreased by 6% from 1.74 per 1,000 population to 1.63 per 1,000 population during the same period. A number of markers of health resource utilization were more prevalent in pneumonic exacerbations than in nonpneumonic exacerbations: length of stay (median 7 vs 4 days), intensive care unit admission (7.7% vs 12.5%), and several acute procedures. Thirty-day mortality was 12.1% in first-time pneumonic COPD exacerbations versus 8.3% in first-time nonpneumonic cases (adjusted HR [aHR] 1.20, 95% confidence interval [CI] 1.17-1.24). Pneumonia also predicted increased mortality associated with a second exacerbation (aHR 1.14, 95% CI 1.11-1.18), and up to a seventh or greater exacerbation (aHR 1.10, 95% CI 1.07-1.13). In contrast, the aHR of a subsequent exacerbation was 8%-13% lower for patients with pneumonic exacerbations.

conclusionsPneumonia is frequent among patients hospitalized for COPD exacerbations and is associated with increased health care utilization and higher mortality. Nonpneumonic COPD exacerbations predict increased risk of subsequent exacerbations.

Indexed as

AdultAgedAged, 80 and overDenmarkDisease ProgressionFemaleHealth ResourcesHospitalizationHospital MortalityHumansIncidenceMaleMiddle AgedPneumoniaPulmonary Disease, Chronic ObstructiveCOPDexacerbationincidencemortalitypneumonia

Identifiers

PMID27042038
PMCPMC4780743

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.