SynthesisDrug design, development and therapy2016
Efficacy of nystatin for the treatment of oral candidiasis: a systematic review and meta-analysis.
Synthesis in Drug design, development and therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 203 citations in OpenAlex.
- Addition of Selenium to Silver Nanoparticles: An Approach to Enhance Their Antimicrobial and Biological Properties - Systematic Review.Biological trace element research · 2026Pooled it
- The effectiveness of microwave disinfection in treating Candida-associated denture stomatitis: a systematic review and metaanalysis.Clinical oral investigations · 2020Pooled it
- Clinical feasibility of chairside methylene blue-mediated photodynamic therapy for oral candidiasis.BMC oral health · 2026Trial
- Antimicrobial photodynamic therapy in the treatment of oral erythematous candidiasis: a controlled and randomized clinical trial.Clinical oral investigations · 2023Trial
- Efficacy and Safety of Fluconazole Mucoadhesive Patches in Human Immunodeficiency Virus-Related Oral Candidiasis.Journal of the International Association of Providers of AIDS CareTrial
- Photodynamic therapy-induced anticandidal effects via reactive oxygen species generation from bisdemethoxycurcumin and potassium iodide.Scientific reports · 2026Article
- Comprehensive Profiling of Aseer Medicinal Plants: Connections Between Molecular Identity, Chemical Composition, and Antifungal-Antibiofilm Activity Against Oral Yeasts.Microorganisms · 2026Article
- Clinical and Microbiological Profile of Oral Candidiasis: A Retrospective Study.Pathogens (Basel, Switzerland) · 2026Article
- A Chlorhexidine Nanocarrier Strategy to Combat Oral Candidiasis Microcosm Biofilms.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Liver Transplantation Without Systemic Antifungal Prophylaxis-An Exceptional Perspective from a Single Center Experience.Journal of clinical medicine · 2025Article
- Characterization and virulence of yeasts associated with neonatal thrush.BMC microbiology · 2025Article
- In Vitro Evaluation of Flexural Strength, Impact Strength, and Surface Microhardness of Vaccinium macrocarpon Reinforced Polymethyl Methacrylate Denture Base Resin.Clinical and experimental dental research · 2025Article
- Near-Infrared Probes Designed with Hemicyanine Fluorophores Featuring Rhodamine and 1,8-Naphthalic Derivatives for Viscosity and HSA Detection in Live Cells.ACS applied bio materials · 2025Article
- Enhancing Antifungal Efficacy and Stability of Nystatin Liposomes Through Chitosan and Alginate Layer-by-Layer Coating: In vitro Studies AgainstInternational journal of nanomedicine · 2025Article
- Comparative Antifungal Efficacy of Curcumin Plus Nystatin Versus Nystatin Monotherapy for Treatment of Denture Stomatitis: A Clinical Trial.Frontiers in dentistry · 2025Article
- Designing, Characterization, and Optimization of Nystatin Loaded Mucoadhesive Spanlastical Hard Candy Lozenges as a Treatment of Oral Candidiasis: An in-vivo Study on Rats.Drug design, development and therapy · 2025Article
- The evolution of antifungal therapy: Traditional agents, current challenges and future perspectives.Current research in microbial sciences · 2025Review
- The Significance of Mono- and Dual-Effective Agents in the Development of New Antifungal Strategies.Chemical biology & drug design · 2025Review
- Optical Properties and Antimicrobial Activity of Si/PVP Hybrid Material Combined with Antibiotics.Molecules (Basel, Switzerland) · 2024Article
- Moxidectin elevates Candida albicans ergosterol levels to synergize with polyenes against oral candidiasis.Applied microbiology and biotechnology · 2024Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo systematically review and assess the efficacy, different treatment protocols (formulation, dosage, and duration), and safety of nystatin for treating oral candidiasis.
methodsFour electronic databases were searched for trials published in English till July 1, 2015. Randomized controlled trials comparing nystatin with other antifungal therapies or a placebo were included. Clinical and/or mycological cure was the outcome evaluation. A meta-analysis or descriptive study on the efficacy, treatment protocols, and safety of nystatin was conducted.
resultsThe meta-analysis showed that nystatin pastille was significantly superior to placebo in treating denture stomatitis. Nystatin suspension was not superior to fluconazole in treating oral candidiasis in infants, children, or HIV/AIDS patients. The descriptive investigations showed that administration of nystatin suspension and pastilles in combination for 2 weeks might achieve a higher clinical and mycological cure rate, and using the nystatin pastilles alone might have a higher mycological cure rate, when compared with using nystatin suspensions alone. Nystatin pastilles at a dose of 400,000 IU resulted in a significantly higher mycological cure rate than that administrated at a dose of 200,000 IU. Furthermore, treatment with nystatin pastilles for 4 weeks seemed to have better clinical efficacy than treatment for 2 weeks. Descriptive safety assessment showed that poor taste and gastrointestinal adverse reaction are the most common adverse effects of nystatin.
conclusionNystatin pastille was significantly superior to placebo in treating denture stomatitis, while nystatin suspension was not superior to fluconazole in treating oral candidiasis in infants, children, or HIV/AIDS patients. Indirect evidence from a descriptive study demonstrated that administration of nystatin pastille alone or pastille and suspension in combination is more effective than that of suspension alone; prolonged treatment duration for up to 4 weeks can increase the efficacy of nystatin. More well designed and high quality randomized control studies are needed to confirm these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.