ArticlePharmacognosy magazine2016
New Isorhamnetin Derivatives from Salsola imbricata Forssk. Leaves with Distinct Anti-inflammatory Activity.
Article in Pharmacognosy magazine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed.
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- A comprehensive metabolomic study of three Egyptian Salsola species revealed their potential anti-inflammatory activity.Scientific reports · 2025Article
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- Comparison ofRSC advances · 2023Article
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- Isolation of New Constituents from Whole Plant ofACS omega · 2022Article
- GenusPlants (Basel, Switzerland) · 2022Review
- Antiviral zinc oxide nanoparticles mediated by hesperidin and in silico comparison study between antiviral phenolics as anti-SARS-CoV-2.Colloids and surfaces. B, Biointerfaces · 2021Article
- Synergistic Effect of Mandarin Peels and Hesperidin with Sodium Nitrite against Some Food Pathogen Microbes.Molecules (Basel, Switzerland) · 2021Article
- Phytochemical Analysis, Pharmacological and Safety Evaluations of Halophytic Plant,Molecules (Basel, Switzerland) · 2021Article
- Anti-Microbial, Anti-Oxidant, and α-Amylase Inhibitory Activity of Traditionally-Used Medicinal Herbs: A Comparative Analyses of Pharmacology, and Phytoconstituents of Regional Halophytic Plants' Diaspora.Molecules (Basel, Switzerland) · 2020Article
- Isolation of Myricitrin and 3,5-di-O-Methyl Gossypetin fromMolecules (Basel, Switzerland) · 2019Article
- Microbial Flora Associated with the Halophyte-Frontiers in microbiology · 2018Article
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4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSalsola imbricata Forssk. is a shrub widely growing in Egypt, used as a camel food, traditionally, used as anti-inflammatory agent. Literature survey showed no report about the anti-inflammatory activity of S. imbricata. AIM OF THE STUDY: This work was designed to study the phenolic constituents and to provide evidence for the traditional use of S. imbricata as an anti-inflammatory agent. MATERIALS AND
methodsThe in vitro anti-inflammatory activity of the total aqueous methanol extract and some isolated compounds were investigated in RAW 264.7 macrophage cells using nitric oxide assay. All chemical structures were identified on the basis of electrospray ionization-mass spectrometry, one- and two-dimension nuclear magnetic resonance.
resultsNine phenolic compounds, among them two new natural products; isorhamnetin-3-O-β-D-glucuronyl (1'''→4'') glucuronide (1) and its dimethyl ester; isorhamnetin-3-O-β-D-di glucuronate dimethyl ester (2), two isorhamnetin glycosides: Isorhamnetin-3-O-β-D-galactopyranoside (3), isorhamnetin-3-O-β-D-glucopyranoside (4), and isorhamnetin (5). In addition, an alkaloidal phenolic; trans N-feruloyl tyramine (6), three phenolic acids: Isovanillic acid (7), ferulic acid (8), and p-hydroxy benzoic acid (9) were isolated from salsola imbricata leaves. All compounds were isolated and identified for the first time from this plant except compound (6). The extract and the tested compounds showed distintict anti-inflammatory activities with no toxicity on RAW 264.7 macrophage cells.
conclusionThe extract and the tested compounds showed distintict anti-inflammatory activities with no toxicity on RAW 264.7 macrophage cells. SUMMARY: Investigation of the chemical constituents of the leaves of Salsola imbricata led to isolation of two new isorhamnetin derivatives: isorhamnetin.3-O-β-D.glucuronyl (1'"→") glucuronide (1) and its dimethyl ester (2), together with seven known phenolic compounds. The extract and the tested compounds showed distintict anti-inflammatory activities with no toxicity on RAW 264.7 macrophage cells. Abbreviations used: PC: Paper chromatography, MPLC : Medium Pressure Liquid Chromatography, HMBC: Heteronuclear multiple bond correlation, HMQC: Heteronuclear single quantum correlation, NMR: Nuclear magnetic resonance.
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