ReviewAustralian prescriber2016
Management of digoxin toxicity.
Review in Australian prescriber, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 94 citations in OpenAlex.
- Digoxin Dosing Errors, Drug Interactions and Off-Label Risks: Insights from an EudraVigilance Disproportionality Analysis.Journal of clinical medicine · 2026Article
- Potential Links Between Aging, Mitochondrial Dysfunction, and Drug Transporter Function-Molecular Mechanisms and Pharmacokinetic Implications.International journal of molecular sciences · 2026Review
- Digoxin Toxicity in Renal Failure: Resolution With Plasma Exchange After Fab Therapy Failure.Cureus · 2025Article
- Review
- Digoxin and its NaBioorganic & medicinal chemistry · 2024Review
- Successful management of massive digoxin overdose using DIGIFab and therapeutic plasma exchange: a case report.Journal of medical case reports · 2024Article
- A Comprehensive Review on Unveiling the Journey of Digoxin: Past, Present, and Future Perspectives.Cureus · 2024Review
- Treatment of life-threatening digoxin toxicity with digoxin-specific antibody fragments: results from a prospective, non-interventional observational UK patient registry study.European journal of hospital pharmacy : science and practice · 2023Observational
- Tejocote Root's Role in Symptomatic Mobitz Type 1 Heart Block: A Compelling Case Report.Cureus · 2023Article
- Atrial Fibrillation Management: A Comprehensive Review with a Focus on Pharmacotherapy, Rate, and Rhythm Control Strategies.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2022Review
- Functional human cell-based vascularised cardiac tissue model for biomedical research and testing.Scientific reports · 2022Article
- Case Report: Clinical Presentation of Toad Venom-Induced Cardiac Intoxication.Journal of acute medicine · 2022Article
- Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina.Stem cells translational medicine · 2022Article
- ST depressions with left ventricular hypertrophy: an electrocardiogram challenge.European heart journal. Case reports · 2022Article
- Predictive Factors for Recurrence of Serious Arrhythmias in Patients with Acute Digoxin Poisoning.Cardiovascular toxicology · 2021Article
- A Visual Resolution of Cardiotoxicity: A Case Report of Digoxin-Induced Bidirectional Ventricular Tachycardia.Cureus · 2021Article
- Symptomatic digoxin toxicity in a patient on haemodialysis.BMJ case reports · 2020Article
- Article
- Effects of Drugs and Excipients on Hydration Status.Nutrients · 2019Review
- Computational drug repurposing for inflammatory bowel disease using genetic information.Computational and structural biotechnology journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Digoxin toxicity can emerge during long-term therapy as well as after an overdose. It can occur even when the serum digoxin concentration is within the therapeutic range. Toxicity causes anorexia, nausea, vomiting and neurological symptoms. It can also trigger fatal arrhythmias. There is a range of indications for using digoxin-specific antibody fragments. The amount ingested and serum digoxin concentration help to determine the dose required, but are not essential. Digoxin-specific antibody fragments are safe and effective in severe toxicity. Monitoring should continue after treatment because of the small risk of rebound toxicity. Restarting therapy should take into account the indication for digoxin and any reasons why the concentration became toxic.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.