ArticleEuropean journal of epidemiology2016
Statin use and risk of glioma: population-based case-control analysis.
Article in European journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Ionizing radiation exposure during adulthood and risk of developing central nervous system tumors: systematic review and meta-analysis.Scientific reports · 2022Pooled it
- Pooled it
- Testing for causality between systematically identified risk factors and glioma: a Mendelian randomization study.BMC cancer · 2020Pooled it
- Life-style and metabolic factors do not affect risk for glioma: a prospective population-based study (The Cohort of Norway).Frontiers in oncology · 2024Article
- Repositioning of HMG-CoA Reductase Inhibitors as Adjuvants in the Modulation of Efflux Pump-Mediated Bacterial and Tumor Resistance.Antibiotics (Basel, Switzerland) · 2023Review
- Role of DNA methylation in the relationship between glioma risk factors and glioma incidence: a two-step Mendelian randomization study.Scientific reports · 2023Article
- XGBoost algorithm and logistic regression to predict the postoperative 5-year outcome in patients with glioma.Annals of translational medicine · 2022Article
- Cholesterol metabolism and its implication in glioblastoma therapy.Journal of Cancer · 2022Review
- Promotion of Ros-mediated Bax/Cyt-c apoptosis by polyphyllin II leads to suppress growth and aggression of glioma cells.Translational cancer research · 2021Article
- Statins: a repurposed drug to fight cancer.Journal of experimental & clinical cancer research : CR · 2021Review
- Predicting factors of tumor progression in adult patients with low-grade glioma within five years after surgery.Translational cancer research · 2021Article
- Reduction of SCUBE3 by a new marine-derived asterosaponin leads to arrest of glioma cells in G1/S.Oncogenesis · 2020Article
- Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma.Cancer medicine · 2020Article
- Risk factors for childhood and adult primary brain tumors.Neuro-oncology · 2019Review
- Statin use, hyperlipidemia, and risk of glioma.European journal of epidemiology · 2019 · on this mapArticle
- Lovastatin Enhances Cytotoxicity of Temozolomide via Impairing Autophagic Flux in Glioblastoma Cells.BioMed research international · 2019Article
- Drug Repurposing of Metabolic Agents in Malignant Glioma.International journal of molecular sciences · 2018Review
- The replication crisis in epidemiology: snowball, snow job, or winter solstice?Current epidemiology reports · 2018Article
- Use of MendelianFrontiers in genetics · 2018Review
- Forkhead Box M1 positively regulates UBE2C and protects glioma cells from autophagic death.Cell cycle (Georgetown, Tex.) · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Statins have been reported to decrease the incidence of cancer, but the risk of glioma among statin users has been investigated in only two prior observational studies, both of them suggesting a modest protective effect of statins. We conducted a matched case-control study using data from the UK-based Clinical Practice Research Datalink to analyse use of statins among 2469 cases with glioma and 24,690 controls. We performed conditional logistic regression analysis to calculate relative risks, estimated as odds ratios (ORs) with 95 % confidence intervals (CIs) adjusting for multiple confounding factors. As compared with non-use of statins, use of statins was not associated with risk of glioma (OR for ≥90 prescriptions=0.75; 95 % CI 0.48-1.17). Our findings do not support previous sparse evidence of a possible inverse association between statin use and glioma risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.