ArticleScientific reports2016
Kurtosis fractional anisotropy, its contrast and estimation by proxy.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- High-Resolution Diffusion Kurtosis Imaging of Hippocampus Subfields Across the Healthy Lifespan.NMR in biomedicine · 2026Article
- gKFA: a geometric framework for kurtosis fractional anisotropy.Scientific reports · 2026Article
- Age-related auditory nerve deficits propagate central gain throughout the auditory system: Associations with cortical microstructure and speech recognition.Neurobiology of aging · 2026Article
- Advanced Quantitative Microstructure Imaging in Autism: A Review of Methodology, Group Differences, and Associations With Developmental Outcomes.Autism research : official journal of the International Society for Autism Research · 2025Review
- Monoexponential and advanced diffusion-weighted imaging for hepatic fibrosis staging based on high inter-examiner reliability.Saudi medical journal · 2024Article
- Detection of recurrent high-grade glioma using microstructure characteristics of distinct metabolic compartments in a multimodal and integrative 18F-FET PET/fast-DKI approach.European radiology · 2024Article
- Diffusion kurtosis imaging tractography reveals disrupted white matter structural networks in children with obstructive sleep apnea syndrome.Brain imaging and behavior · 2024Article
- Biophysical modeling and diffusion kurtosis imaging reveal microstructural alterations in normal-appearing white-matter regions of the brain in obstructive sleep apnea.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Relating white matter microstructure in theoretically defined addiction networks to relapse in alcohol use disorder.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- Microstructural white matter alterations in Alzheimer's disease and amnestic mild cognitive impairment and its diagnostic value based on diffusion kurtosis imaging: a tract-based spatial statistics study.Brain imaging and behavior · 2022Article
- Microstructural white matter alterations in Alzheimer's disease and amnestic mild cognitive impairment and its diagnostic value based on diffusion kurtosis imaging: a tract-based spatial statistics study.Brain imaging and behavior · 2022Article
- Quantitative Diffusion and Spectroscopic Neuroimaging Combined with a Novel Early-Developmental Assessment Improves Models for 1-Year Developmental Outcomes.AJNR. American journal of neuroradiology · 2022Article
- Apparent propagator anisotropy from single-shell diffusion MRI acquisitions.Magnetic resonance in medicine · 2021Article
- Article
- Diffusional Kurtosis Imaging in the Diffusion Imaging in Python Project.Frontiers in human neuroscience · 2021Article
- Potential Pitfalls of Using Fractional Anisotropy, Axial Diffusivity, and Radial Diffusivity as Biomarkers of Cerebral White Matter Microstructure.Frontiers in neuroscience · 2021Review
- Visualization of live, mammalian neurons during Kainate-infusion using magnetic resonance microscopy.NeuroImage · 2020Article
- Diffusion Kurtosis Imaging maps neural damage in the EAE model of multiple sclerosis.NeuroImage · 2020Article
- Diffusion Kurtosis Imaging as a Tool in Neurotoxicology.Neurotoxicity research · 2020Article
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Abstract
The diffusion kurtosis observed with diffusion magnetic resonance imaging (dMRI) may vary with direction. This directional variation is summarized in the scalar kurtosis fractional anisotropy (KFA). Recent studies suggest that kurtosis anisotropy offers microstructural contrast not contained in other commonly used dMRI markers. We compare KFA to other dMRI contrasts in fixed rat brain and in human brain. We then investigate the observed contrast differences using data obtained in a physical phantom and simulations based on data from the phantom, rat spinal cord, and human brain. Lastly, we assess a strategy for rapid estimation of a computationally modest KFA proxy by evaluating its correlation to true KFA for varying number of sampling directions and signal-to-noise ratio (SNR) levels. We also map this proxy's b-value dependency. We find that KFA supplements the contrast of other dMRI metrics - particularly fractional anisotropy (FA) which vanishes in near orthogonal fiber arrangements where KFA does not. Simulations and phantom data support this interpretation. KFA therefore supplements FA and could be useful for evaluation of complex tissue arrangements. The KFA proxy is strongly correlated to true KFA when sampling is performed along at least nine directions and SNR is high.
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