ArticleDocumenta ophthalmologica. Advances in ophthalmology2016
Witnessing the first sign of retinitis pigmentosa onset in the allegedly normal eye of a case of unilateral RP: a 30-year follow-up.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Wavelet-Based Pattern ERG Biomarkers Outperform Temporal Amplitude Measures for Functional Stratification in Optic Nerve Disease.Translational vision science & technology · 2026Article
- Ocular and Systemic Phenotyping of Bardet-Biedel Syndrome Type 7 (BBS7) in a Palestinian Male: Case Report and Literature Review.Case reports in ophthalmological medicine · 2026Article
- Multidimensional Quantification of Macular Cone Activity in Pattern Electroretinography Using Discrete Wavelet Transform.Translational vision science & technology · 2025Article
- Hilbert transform analysis of the mouse scotopic electroretinogram reveals two distinct bursts of oscillatory potentials with progressively dimmer flashes.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Resting state electroretinography: An innovative approach to intrinsic retinal function monitoring.Frontiers in physiology · 2022Article
- Continuous wavelet transform analysis of ERG in patients with diabetic retinopathy.Documenta ophthalmologica. Advances in ophthalmology · 2021Article
- Unilaterally extinguished electroretinograms in an eye with normal visual acuity and visual field.Documenta ophthalmologica. Advances in ophthalmology · 2021Observational
- Distinguishing Familial from Acquired Traits in the Retinal Blood Vessel Arborization.Translational vision science & technology · 2020Article
- Analysis of pattern electroretinogram signals of early primary open-angle glaucoma in discrete wavelet transform coefficients domain.International ophthalmology · 2019Article
- Time and frequency components of ERG responses in retinitis pigmentosa.International ophthalmology · 2018Article
- The DTL ERG electrode comes in different shapes and sizes: Are they all good?Documenta ophthalmologica. Advances in ophthalmology · 2017Article
- Wavelet decomposition analysis in the two-flash multifocal ERG in early glaucoma: a comparison to ganglion cell analysis and visual field.Documenta ophthalmologica. Advances in ophthalmology · 2017Article
- Quantifying the ON and OFF Contributions to the Flash ERG with the Discrete Wavelet Transform.Translational vision science & technology · 2017Article
- Assessing the Contribution of the Oscillatory Potentials to the Genesis of the Photopic ERG with the Discrete Wavelet Transform.BioMed research international · 2016Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
purposeA patient initially presented with constricted visual field, attenuated retinal vasculature, pigmentary clumping and reduced ERG in OS only, suggestive of unilateral retinitis pigmentosa (RP). This patient was subsequently seen on eight occasions (over three decades), and, with time, the initially normal eye (OD) gradually showed signs of RP-like degeneration. The purpose of this study was to evaluate which clinical modality (visual field, funduscopy or electroretinography) could have first predicted this fate.
methodsAt each time points, data obtained from our patient were compared to normative data using Z tests.
resultsAt initial visit, all tests were significantly (p < 0.05) altered in OS and normal in OD. Visual field and retinal vessel diameter in OD reduced gradually to reach statistical significance at the 5th visit and 6th visit (21 and 22 years after the first examination, respectively). In OD, the amplitude of the scotopic and photopic ERGs reduced gradually and was significantly smaller than normal at the 2nd visit (after 11 years) and 3rd visit (after 18 years), respectively. When the photopic ERG was analyzed using the discrete wavelet transform (DWT), we were able to detect a significant change at the 2nd visit (after 11 years) instead of the 3rd visit (18 years).
conclusionsOur study allowed us to witness the earliest manifestation of an RP disease process. The ERG was the first test to detect significant RP changes. A significantly earlier detection of ERG anomalies was obtained when the DWT was used, demonstrating its advantage for early detection of ERG changes.
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