ArticleInternational journal of colorectal disease2016
Hyperbaric oxygen therapy improves colorectal anastomotic healing.
Article in International journal of colorectal disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Meta-analysis on the effect of hyperbaric oxygen as adjunctive therapy in the outcome of anastomotic healing of experimental colorectal resections in rats.Diving and hyperbaric medicine · 2018Pooled it
- Observational
- Macrophages in Intestinal Wound Healing: Dichotomous Effects and Therapeutic Opportunities.International journal of molecular sciences · 2026Review
- Hyperbaric oxygen therapy in the treatment of severe gastric laceration with active bleeding: A case report.World journal of gastrointestinal endoscopy · 2025Article
- What Is the Role of the Gut Microbiota in Anastomotic Leakage After Colorectal Resection? A Scoping Review of Clinical and Experimental Studies.Journal of clinical medicine · 2024Article
- Experimental models of high-risk bowel anastomosis in rats: A systematic review.World journal of experimental medicine · 2024Article
- The new insights of hyperbaric oxygen therapy: focus on inflammatory bowel disease.Precision clinical medicine · 2024Review
- Effects of adipose tissue-derived mesenchymal stem cells and/or sildenafil citrate in experimental colon anastomosis model.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2022Article
- Article
- Ischemic proctitis 6 months after laparoscopic sigmoidectomy: a case report.Surgical case reports · 2021Article
- Study of the Effect of Hyperbaric Oxygen Therapy on the Viability of Dorsal Cutaneous Flaps in Tobacco-Exposed Rats.Aesthetic plastic surgery · 2020Article
- Experimental fortification of intestinal anastomoses with nanofibrous materials in a large animal model.Scientific reports · 2020Article
- Effect of preconditioning and postoperative hyperbaric oxygen therapy on colonic anastomosis healing with and without ischemia in rats.Acta cirurgica brasileira · 2020Article
- Effect of oxygen-producing suture material on hypoxic colonic anastomoses in an experimental model.BJS open · 2019Article
- The triune of intestinal microbiome, genetics and inflammatory status and its impact on the healing of lower gastrointestinal anastomoses.The FEBS journal · 2018Review
- The yet-to-be discovered mechanism of anastomotic leakage-comment to: Lack of evidence for tissue hypoxia as a contributing factor in anastomotic leak following colon anastomosis and segmental devascularization in rats.International journal of colorectal disease · 2017Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeHyperbaric oxygen treatment (HBOT) has been found to improve the healing of poorly oxygenated tissues. This study aimed to investigate the influence of HBOT on the healing in ischemic colorectal anastomosis.
methodsForty Wistar rats were randomly divided into a treatment group that received HBOT for 10 consecutive days (7 days before and 3 days after surgery), or in a control group, which did not receive the therapy. Colectomy with an ischemic anastomosis was performed in all rats. In each group, the rats were followed for 3 or 7 days after surgery to determine the influence of HBOT on anastomotic healing.
resultsFive rats from each group died during follow-up. No anastomotic dehiscence was seen in the HBOT group, compared to 37.5 % and 28.6 % dehiscence in the control group on postoperative day (POD) 3 and 7, respectively. The HBOT group had a significantly higher bursting pressure (130.9 ± 17.0 mmHg) than the control group (88.4 ± 46.7 mmHg; p = 0.03) on POD 3. On POD 3 and POD 7, the adhesion severity was significantly higher in the control groups than in the HBOT groups (p < 0.005). Kidney function (creatinine level) of the HBOT group was significantly better than of the control group on POD 7 (p = 0.001). Interestingly, a significantly higher number of CD206+ cells (marker for type 2 macrophages) was observed in the HBOT group at the anastomotic area on POD 3.
conclusionHyperbaric oxygen enhanced the healing of ischemic anastomoses in rats and improved the postoperative kidney function.
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