ArticleNature communications2016
Ancient human sialic acid variant restricts an emerging zoonotic malaria parasite.
Article in Nature communications, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Article
- Replication stress increases de novo CNVs across the malaria parasite genome.Nucleic acids research · 2026Article
- Sialyl-T Antigen: A Novel Red Blood Cell Determinant for Plasmodium falciparum Invasion.American journal of hematology · 2025Article
- Replication stress increases de novo CNVs across the malaria parasite genome.bioRxiv : the preprint server for biology · 2025Article
- A General Principle of Neuronal Evolution Reveals a Human-Accelerated Neuron Type Potentially Underlying the High Prevalence of Autism in Humans.Molecular biology and evolution · 2025Article
- Discovery and characterization of vertebrate sialoglycan-binding proteins.Seminars in immunology · 2025Review
- The essential genome ofScience (New York, N.Y.) · 2025Article
- Supersaturation mutagenesis reveals adaptive rewiring of essential genes among malaria parasites.Science (New York, N.Y.) · 2025Article
- A general principle of neuronal evolution reveals a human-accelerated neuron type potentially underlying the high prevalence of autism in humans.bioRxiv : the preprint server for biology · 2025Article
- Sialic acid in the regulation of blood cell production, differentiation and turnover.Immunology · 2024Review
- Evolutionary constraint and innovation across hundreds of placental mammals.Science (New York, N.Y.) · 2023Article
- Merozoite surface protein 1 paralog is involved in the human erythrocyte invasion of a zoonotic malaria,Frontiers in cellular and infection microbiology · 2023Article
- Red Blood Cells Oligosaccharides as Targets for Plasmodium Invasion.Biomolecules · 2022Review
- Plasmodium knowlesi: the game changer for malaria eradication.Malaria journal · 2022Review
- Review
- Clinical recovery of Macaca fascicularis infected with Plasmodium knowlesi.Malaria journal · 2021Article
- Sialic Acids as Receptors for Pathogens.Biomolecules · 2021Review
- Unveiling the Sugary Secrets ofFrontiers in microbiology · 2021Review
- Ape Origins of Human Malaria.Annual review of microbiology · 2020Review
- Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention.Nature communications · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Plasmodium knowlesi is a zoonotic parasite transmitted from macaques causing malaria in humans in Southeast Asia. Plasmodium parasites bind to red blood cell (RBC) surface receptors, many of which are sialylated. While macaques synthesize the sialic acid variant N-glycolylneuraminic acid (Neu5Gc), humans cannot because of a mutation in the enzyme CMAH that converts N-acetylneuraminic acid (Neu5Ac) to Neu5Gc. Here we reconstitute CMAH in human RBCs for the reintroduction of Neu5Gc, which results in enhancement of P. knowlesi invasion. We show that two P. knowlesi invasion ligands, PkDBPβ and PkDBPγ, bind specifically to Neu5Gc-containing receptors. A human-adapted P. knowlesi line invades human RBCs independently of Neu5Gc, with duplication of the sialic acid-independent invasion ligand, PkDBPα and loss of PkDBPγ. Our results suggest that absence of Neu5Gc on human RBCs limits P. knowlesi invasion, but that parasites may evolve to invade human RBCs through the use of sialic acid-independent pathways.
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