Evidence map›Paper›PMID 27041121›Full record

SynthesisEuropean journal of pediatrics2016

Motivations of children and their parents to participate in drug research: a systematic review.

Krista Tromp, C Michel Zwaan, Suzanne van de Vathorst

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  4. Facilitators and barriers of children's participation in nutrition, physical activity, and obesity interventions: A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021
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  6. Investigating Effects of Mentoring for Youth with Assault Injuries: Results of a Randomized-Controlled Trial.Prevention science : the official journal of the Society for Prevention Research · 2022
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  7. Journal of child health care : for professionals working with children in the hospital and community · 2022
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  10. Evaluation of an Interactive, Educational Website Developed for Adolescents to Learn About Pediatric Clinical Trials: DigiKnowIt News.Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Krista TrompDepartment of Medical Ethics and Philosophy of Medicine, Erasmus MC, P.O. box 2040, 3000, CA, Rotterdam, The Netherlands. K.tromp@erasmusmc.nl.
C Michel ZwaanDepartment of Pediatric Oncology/Hematology, Erasmus MC-Sophia Children's Hospital, P.O. box 2040, 3000, CA, Rotterdam, The Netherlands.
Suzanne van de VathorstDepartment of Medical Ethics and Philosophy of Medicine, Erasmus MC, P.O. box 2040, 3000, CA, Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledInformation on motivations for research participation, may enable professionals to better tailor the process of recruitment and informed consent to the perspective of parents and children. Therefore, this systematic review assesses motivating and discouraging factors for children and their parents to decide to participate in clinical drug research. Studies were identified from searches in 6 databases. Two independent reviewers screened and selected relevant articles. Results were aggregated and presented by use of qualitative metasummary. 38 studies fulfilled the selection criteria and were of sufficient quality for inclusion in the qualitative metasummary. Most mentioned motivating factors for parents were: health benefit for child, altruism, trust in research, and relation to researcher. Most mentioned motivating factors for children were: personal health benefit, altruism and increasing comfort. Fear of risks, distrust in research, logistical aspects and disruption of daily life were mentioned most by parents as discouraging factors. Burden and disruption of daily life, feeling like a "guinea pig" and fear of risks were most mentioned as discouraging factors by children.

conclusionPaying attention to these motivating and discouraging factors of children and their parents during the recruitment and informed consent process in drug research increases the moral and instrumental value of informed consent. WHAT IS KNOWN: • This systematic review pools the existing empirical literature on motivations of minors and their parents to consent or dissent to participation in clinical drug research. • The most mentioned motivating and discouraging factors for children and their parents to consent to participation in clinical drug research are identified aggregated and presented by use of qualitative metasummary. What is new: • This information can be used to adapt the research protocol, recruitment, and informed consent/assent process to the needs of children and their parents.

Indexed as

Decision MakingMotivationPharmaceutical ResearchChildHumansInformed ConsentParental ConsentResearch SubjectsSurveys and QuestionnairesChildClinical drug researchEthicsMotivationsParentsParticipation

Identifiers

PMID27041121
PMCPMC4839044

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.